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EC number: 240-759-7 | CAS number: 16712-64-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1983-09-27 - 1983-12-2
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP and guideline conforming study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- of 1981
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-hydroxy-2-naphthoic acid
- EC Number:
- 202-180-8
- EC Name:
- 3-hydroxy-2-naphthoic acid
- Cas Number:
- 92-70-6
- IUPAC Name:
- 3-hydroxy-2-naphthoic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): BONS TTR
- Substance type: light yellowish powder
- Physical state: solid
- Analytical purity:
- Impurities (identity and concentrations): about 1% ß-Naphthol
- Lot/batch No.: 1297/83
- Storage condition of test material: at about 22°C in the dark
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hoechst AG breeding colony
- Weight at study initiation: male 197 g (mean); female 191 g (mean)
- Fasting period before study: 16h
- Housing: makrolon cage, groups of 5
- Diet (e.g. ad libitum): rat diet Altromin 1324, ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 2
- Humidity (%): 55 +/- 10
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- 2% aqueous carboxymethyl cellulose (CMC)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 25%
- Amount of vehicle (if gavage): 1.25ml/kg bw in the lowest dose group and 5.0 ml/kg bw in the highest dose group - Doses:
- male: 800, 1000, 1250 mg/kg bw
female: 315, 500, 800, 1000, 1250 mg/kg bw - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
weighth was determined: 0, 7, 14 days post application,
clinical signes were observed: 10, 30, 60 min; 2, 4, 6 h, 1, 2, 3, 4-14 d post application
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- Probit analysis
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 823 mg/kg bw
- 95% CL:
- >= 581 - <= 1 070
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 869 mg/kg bw
- 95% CL:
- >= 394 - <= 1 350
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 795 mg/kg bw
- 95% CL:
- >= 485 - <= 1 320
- Mortality:
- 315 mg/kg bw : 0/5 (f)
500 mg/kg bw: 2/5 (f)
800 mg/kg bw: 1/5 (m), 2/5 (f)
1000 mg/kg bw: 3/5 (m), 3/5 (f)
1250 mg/kg bw: 5/5 (m), 4/5 (f)
all deaths occured 35 - 200 min. post application - Clinical signs:
- other: Similar clinical signs were observed in both sexes. Clinical signes included reduced activity, accelerated breathing, closure of eyes and diarrhea (occurring 30-60 min post application).
- Gross pathology:
- Surviving animals were free of pathological changes at the end of the observation period (14 d). Gastrointestinal irritation and dark or mottled livers were observed in the dead animals.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information REGULATION (EC) No 1272/2008 Criteria used for interpretation of results: EU
- Conclusions:
- LD50 male/female: 823 mg/kg bw
LD50 male: 869 mg/kg bw
LD50 female: 795 mg/kg bw - Executive summary:
3-Hydroxy-2-naphthoic acid was tested for its acute toxicity in the rat according to OECD Guideline 401 and in compliance with GLP. An oral LD50 of 823 mg/kg bw was determined for both sexes, 869 mg/kg for males and 795 mg/kg for females. Mortality occurred within 35 -200 minutes after dosing. Principal clinical signs were reduced spontaneous activity, ventral and lateral recumbency and crawling in all dose groups, in addition to closure of eyes, hunched posture and accelarated breathing in several dose groups starting at approximately 10 to 30 min post administration. In addition, diarrhea was noted in several dose groups starting mainly at approximately 30 to 60 min post administration. As from the day after the administration all surviving animals were free from clinical signs. Bodyweight was unaffected by treatment with the test substance. No macroscopic pathology findings were evident in animals which survived the 14-day post-dosing observation period, whilst dark or mottled livers and signs of gastrointestinal irritation were evident in decedent animals. There was no indication of relevant sex-related differences in toxicity of the substance after single oral administration.
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