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EC number: 206-851-6 | CAS number: 383-63-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin: slightly irritating, not classified (2 key studies, reliability Kr. 2, OECD 404)
Eyes: irritating to eyes (Key study, reliability Kr. 2, OECD 405)
Respiratory irritation: no data
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin irritation:
Two different studies conducted on ethyl trifluoroacetate were considered as key studies. Both studies are not in compliance with GLP but present a good reliability (Kr. 2).
The first key study was conducted in 1983 (Guillot) similarly to the OECD guideline No. 404. Six male New Zealand Albino rabbits, were dermally exposed to 0.5 mL of undiluted Ethyl trifluoroacetate (purity of 97.3%) to the clipped skin of the flank.Test sites were covered with a semi-occlusive dressing for 4 hours. The arithmethic mean scores calculated within 3 scoring times (24, 48 and 72 hrs) were 1.83 for erythema and 0.0 for edema.
The second key study was conducted in 1987 (Liggett) in accordance with the OECD guideline No. 404. Three male New Zealand White rabbits, were dermally exposed to 0.5 mL of undiluted Ethyl trifluoroacetate (purity of 99.7%) to the clipped skin of the dorso-lumbar region.Test sites were covered with a semi-occlusive dressing for 4 hours. The mean individual scores calculated within 3 scoring times (24, 48 and 72 hrs) were 0.0/0.0/0.0 for erythema and 0.0/0.0/0.0 for edema.
Under the test conditions, Ethyl trifluoroacetate is not classified as skin irritant when applied topically to rabbits according to the Regulation (EC) 1272/2008 (CLP) and to the Directive 67/548/EEC.
Eyes irritation:
Two studies were available (Guillot, 1983 and Liggett, 1987). However the study of Guillot was considered as the key study in a worst case strategy as the results of this study conducted to the classification of the substance in category 2. The second study (Liggett, 1987) gave negative results (ie. No eyes irritation was observed) and was therefore considered as a supporting study.
In the key study performed similarly to the OECD No. 405 but not in compliance with the GLP, 0.1 mL of undiluted Ethyl Trifluoroacetate (purity of 97.3%) was instilled into the conjunctival sac of the right eye of 6 male New Zealand albino Rabbits.
The mean scores of all animals were 1.06 for chemosis, 1.1 for conjunctival erythema, 1.78 for corneal opacity and 1.83 for the lesions of the iris to conclude according to the criteria of the Directive 67/548/EEC. Considering another calculation, the mean individual scores were 1.3/1.3/0.3/0.3/1.7/1.3 for chemosis, 1.0/1.7/0.3/0.3/2.0/1.3 for conjunctival erythema, 2.0/1.0/2.0/1.7/2.0/2.0 for corneal opacity and 1.0/1.0/0.0/0.3/1.0/0.3 for the lesions of the iris. In any case, all of these ocular effects were fully reversible within 7 days.
Under the test conditions, as all animals (6/6) presented mean corneal opacity scores higher than 1.0 at 24, 48 and 72h after the end of exposure, Ethyl trifluoroacetate is classified as Eye Irr. 2 (Causes serious eye irritation, H319) according to the Annex I of the Regulation (EC) 1272/2008 (CLP). In another way, as the mean score for iridal lesions of all animals over 24, 48,72h is higher than 1, Ethyl trifluoroacetate is classified as irritating to eyes (Xi, R36) according to criteria of the Annex VI of the Directive 67/548/EEC.
Justification for selection of skin irritation / corrosion endpoint:
Two different studies conducted on ethyl trifluoroacetate were considered as key studies. Both studies are not in compliance with GLP but present a good reliability (Kr. 2).
Justification for selection of eye irritation endpoint:
Two different studies conducted on ethyl trifluoroacetate were considered as key studies. Both studies are not in compliance with GLP but present a good reliability (Kr. 2).
Effects on skin irritation/corrosion: slightly irritating
Effects on eye irritation: irritating
Justification for classification or non-classification
Harmonized classification:
No harmonized classification is available for human health according to the Regulation (EC) No. 1272/2008 including the ATP2.
Self-classification:
Based on the available data:
- ethyl trifluoroacetate is not classified for skin irritation according to the criteria of the Annex I of the Regulation (EC) No 1272/2008 (CLP) and to the criteria of the Annex VI of the Directive 67/548/EEC.
- ethyl trifluoroacetate is self-classified for eye irritation:
-in Category 2 (H319, Causes serious eye irritation) according to the criteria of the Regulation (EC) No 1272/2008 (CLP) since corneal opacity is ≥1 for at least 2/3 animals,
- Xi, R36 (irritating to eyes) according to the criteria of the Annex VI to the Directive 67/548/EEC since corneal opacity is ≥2 for at least 2/3 animals.
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