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EC number: 209-708-6 | CAS number: 591-22-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion
- Remarks:
- in vitro
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Similar to a guideline method but not performed under GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 435 (In Vitro Membrane Barrier Test Method for Skin Corrosion)
- Principles of method if other than guideline:
- An in vitro barrier test method (OECD 435) was employed, using a Color Detection System (CDS) for an irritant. The material was placed on a biobarrier situated on a permeable support membrane, and the time to penetration of the biobarrier and membrane into the indicator solution was measured in 4 replicates.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3,5-dimethylpyridine
- EC Number:
- 209-708-6
- EC Name:
- 3,5-dimethylpyridine
- Cas Number:
- 591-22-0
- Molecular formula:
- C7H9N
- IUPAC Name:
- 3,5-dimethylpyridine
- Test material form:
- other: liquid
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- other: in vitro
- Strain:
- other: in vitro
Test system
- Type of coverage:
- other: in vitro
- Preparation of test site:
- other: in vitro
- Vehicle:
- other: in vitro
- Controls:
- other: positive and negative control substances were included in the test procedure.
- Details on study design:
- The Corrositex (R) test method was used to predict the in vivo corrosive potential of a chemical compound or mixture by using as an endpoint the time it takes for the chemical to permeate through or destroy a synthetic biobarrier. When the chemical has passed through this biobarrier, a visual change is produced in a proprietary Chemical Detection System (CDS). Qualification of the material as appropriate for testing in this procedure is first undertaken by applying either 150 ml of a liquid or 100 mg of a solid into an aliquot of the CDS reagent and observing it for the presence of any detectable change. If a physical or color change is observed, the sample is judged to be compatible with the detection solution and the remainder of the test is performed. The second step of the Corrositex test utilizes appropriate indicator solutions to permit categorization of the test sample as either a Category 1 or Category 2 material. Category 1 materials are typically strong acids/bases, while Category 2 materials are typically weak acids/bases. The third step in the test is performed by applying the test sample to the biobarrier. When the chemical permeates through or destroys the full thickness of this biobarrier, it comes into contact with the CDS which then undergoes a simple color change. This color change is visually observed and the time required for the color change to occur is recorded. Positive and negative controls are analyzed concurrently to confirm the test's validiy. Four replicates of the test substance, applied neat to the the biobarrier, were examined. The time (in minutes, mean ± SD) to breakthough (color change) was calculated.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Corrosion
- Basis:
- mean
- Time point:
- other: Not applicable
- Score:
- > 60
- Reversibility:
- other: not applicable
- Remarks on result:
- other: Mean time to color change was > 60 min, indicating "noncorrosive"
- Irritant / corrosive response data:
- The mean time to color change was > 60 min for four replicates of the test material, tested in an indicator solution identifying irritants. The duration of time > 60 minutes indicates the substance is noncorrosive.
- Other effects:
- The indicator CDS system was for Irritation, Category 2, based on the structure of the test material.
Any other information on results incl. tables
Table 1: Designation of UN Packing Groups
|
Corrositex Time (minutes) |
|||
Category 1 (based on Indicator solutions) |
0 to 3 min. |
>3 to 60 min. |
>60 to 240 min. |
>240 min. |
Category 2 (based on Indicator solutions)
|
0 to 3 min. |
>3 to 30 min. |
>30 to 60 min. |
>60 min. |
Result |
UN Packing Group I |
UN Packing Group II |
UN Packing Group III |
Noncorrosive |
Table 2: Summary of Test Results
IVI#:C2914 |
Corrositex Time (minutes) |
Sample:3,5-Lutidine |
Replicate #1:> 60 |
Conc. Tested:Neat |
Replicate #2:> 60 |
pH:n/a |
Replicate #3:> 60 |
Category:2 |
Replicate #4:> 60 |
Packing Group:NC |
Mean±SD: > 60 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant)
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- 3,5-Dimethylpyridine was tested neat in a Corrositex (R) Biobarrier membrane penetration test. The substance remained on the biobarrier for > 60 minutes, using a color detection system for Category 2 (irritants). This result indicates that the substance is an irritant, but is not corrosive.
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