Registration Dossier
Registration Dossier
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EC number: 208-843-8 | CAS number: 543-39-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study predates OECD guidelines and GLP, but is similar to OECD TG 403.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-methyl-6-methyleneoct-7-en-2-ol
- EC Number:
- 208-843-8
- EC Name:
- 2-methyl-6-methyleneoct-7-en-2-ol
- Cas Number:
- 543-39-5
- Molecular formula:
- C10H18O
- IUPAC Name:
- 2-methyl-6-methylideneoct-7-en-2-ol
- Test material form:
- other: clear liquid
- Details on test material:
- RIFM # 72-39
Recieved: April 11th, 1972
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: pure substance
- Details on dermal exposure:
- The bandage consists of rubber dam gauze and adhesive tape
- Duration of exposure:
- 24 hour
- Doses:
- 1
- No. of animals per sex per dose:
- 10/dose; sex not reported
- Details on study design:
- - Necropsy of survivors performed: not clear from report
- Other examinations performed: skin irritation (time/frequency of observations not reported)
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There were no deaths.
- Clinical signs:
- other: No abnormalities were noted at necropsy.
- Gross pathology:
- All animals were essentially normal by the termination of the study.
- Other findings:
- Skin irritation findings included erythema (slight in 3 animals, moderate in 3 animals) and edema (slight in 4 animals, moderate in animals) on Day 7.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- A LD50 was > 5000 mg/kg bw in an acute dermal toxicity study with rabbits.
- Executive summary:
In an acute dermal toxicity study with rabbits, similar to OECD TG 402 but non-GLP, the LD50 was > 5000 mg/kg bw. A group of 10 animals (strain, sex and age unspecified) received a single application of 5000 mg/kg bw test substance. There were no deaths. Skin irritation findings included erythema (slight in 3 animals, moderate in 3 animals) and edema (slight in 4 animals, moderate in animals) on Day 7.
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