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EC number: 265-512-0 | CAS number: 65140-91-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
No animal studies were conducted with the test substance to investigate possible substance-related effects on the reproductive performance. In a subchronic oral feeding study conducted in male and female CD rats after exposure to 700, 2000, 6000 ppm (corresponding to 40, 122, 376 mg/kg bw/day in males and 48, 136, 420 mg/kg bw/day in females) no findings of pathological significance were noted in testes and epididymis of males as well as in uterus and ovaries of females in comparison with untreated control animals (Huntingdon, 1979). Similarly, in a subchronic oral feeding study conducted in Beagle dogs after exposure to 200, 600, 2000 ppm (corresponding to 8.5, 24.7, 84.1 mg/kg bw/day for males and 9.2, 28.3, 90.2 mg/kg bw/day for female) no findings of pathological significance were noted in testes and epididymis of males as well as in uterus and ovaries of females in comparison with untreated control animals (Life Science Research, 1980).
Short description of key information:
In two subchronic oral feeding study conducted in rats and dogs, no effects on reproductive organs have been observed.
Effects on developmental toxicity
Description of key information
In a prenatal developmental toxicity study (Ciba-Geigy, 1983, OECD 414) 25 pregnant Tif:RAIf (SPF) rats per dose were treated daily by gavage with 400, 1200 and 2400 mg test substance per kg bodyweight from day 6 to 15 of gestation. No adverse effects have been observed. Based on the findings a NOEL of 2400 mg/kg bw (highest dose tested) was deduced for developmental toxicity.
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 2 400 mg/kg bw/day
- Species:
- rat
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
In a prenatal developmental toxicity study following OECD guideline 414, 25 pregnant Sprague-Dawley derived Tif:RAIf (SPF) rats per dose group were treated daily with the test article by gavage at 400, 1200, 2400 mg/kg body weight from day 6 to 15 of gestation. Dams were killed on day 21 and fetuses removed by Caesarian section. Body-weight gain was comparable for the dams of all groups. Food consumption of the experimental groups, however, showed some reduction during the treatment period (from day 6 of pregnancy) in comparison with the vehicle control. One female of the low dose group died due to an intubation error.
The rates of implantation sites per female were comparable for all groups. No differences between control and test groups were reported regarding fetal death (resorption), male to female ratio of fetuses and average fetal body weight. A slight but significant increase was noted for the live fetuses of the intermediate and, at a lower extent, of the high-dose group. This finding, however, is not assumed to be of a biological relevance.
Some instances of anomalies and/or malformations were recorded for the dose groups as well as for the vehicle control: two fetuses from one litter of the low dose displayed subpleural haemorrhage; mandibular aplasia and partial aplasia of the lungs, respectively, were found in one fetus each of the intermediate dose, omphalocele occurred in one fetus of the high dose and anasarca in one fetus of the vehicle control group. These findings are considered to be of a spontaneous origin and not related to the treatment. The incidences of mandibular aplasia, omphalocele and anasarca were found to be 0.05%, 0.04% and 0.12%, respectively, in the historical control population of the breed of rats used for the present experiment. Likewise, the occurrence of sternebral anomalies in all groups was not assumed to be of an experimental significance, the overall incidence of sternebral anomalies being 0.37% in the historical control. Concerning the status of skeletal maturation of the fetuses, no delay of ossification could be found for the experimental groups in comparison with the vehicle control. Based on the findings a NOAEL of 2400 mg/kg body weight (highest dose tested) was derived for maternal and developmental toxicity.
Justification for selection of Effect on developmental toxicity: via oral route:
Guideline study
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
-No classification required for toxicity to reproduction.
Classification, Labeling, and Packaging Regulation (EC) No. 1272/2008:
-No classification required for toxicity to reproduction.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.