Registration Dossier
Registration Dossier
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EC number: 201-152-2 | CAS number: 78-87-5
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1969
- Reliability:
- 2 (reliable with restrictions)
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: List VII.
- Author:
- Smyth, HF, Carpenter, CP, Weil, CS, Pozzani, UC, Streigel,|JA and Nycum, JS
- Year:
- 1 969
- Bibliographic source:
- Am Ind Hyg Assoc J, Sept-Oct 1989, 470 - 476.
- Reference Type:
- publication
- Title:
- Chemical burns of the rabbit cornea
- Author:
- Carpenter, C.P., Smyth, H.F.
- Year:
- 1 946
- Bibliographic source:
- Am. J. Ophthalmol. 25,|1363 - 1
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Method: other: Eye Irritation
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,2-dichloropropane
- EC Number:
- 201-152-2
- EC Name:
- 1,2-dichloropropane
- Cas Number:
- 78-87-5
- Molecular formula:
- C3H6Cl2
- IUPAC Name:
- 1,2-dichloropropane
- Details on test material:
- IUCLID4 Test substance: 1,2 Dichloropropane
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- No data
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 ml- undiluted
- Duration of treatment / exposure:
- No data
- Observation period (in vivo):
- No data
- Number of animals or in vitro replicates:
- No data
- Details on study design:
- Eye injury in rabbits is recorded in a 10-grade ordinal series and is based upon the degree of corneal necrosis that results from instillation of verious volumes and concentrations of chemical. Grade 1 indicates at most a very small area of necrosis resulting from 0.5ml of undiluted chemical in the eye. Grade 5 indicates a so-called sever burn from 0.005ml, and grade 10 indicates a sever burn from 0.5ml of a 1% solution in water or propylene glycol.
Results and discussion
In vivo
- Irritant / corrosive response data:
- Grade 2: slight irritation response
- Other effects:
- No data
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the results of the study irritation index is 2 of 10 maximum and test material is slightly irritating to the eye.
- Executive summary:
Based on the results of the study irritation index is 2 of 10 maximum and test material is slightly irritating to the eye.
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