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EC number: 900-110-7 | CAS number: 5370-08-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 6.- 8. 2.1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: According to OECD guideline (1984) under GLP
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- Principles of method if other than guideline:
- Not relevant
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- (2E)-1,1,4,4-tetramethoxybut-2-ene; (2Z)-1,1,4,4-tetramethoxybut-2-ene
- EC Number:
- 900-110-7
- Cas Number:
- 5370-08-1
- Molecular formula:
- C8H16O4
- IUPAC Name:
- (2E)-1,1,4,4-tetramethoxybut-2-ene; (2Z)-1,1,4,4-tetramethoxybut-2-ene
- Details on test material:
- - Name of test material (as cited in study report): C4-Diacetale
- Physical state: colourless liquid
- Storage condition of test material: In a tightly closed container at room temperature in the dark
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 275 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 241 - 316 mg/L
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 401 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 324 - 506 mg/L
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 180 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
Any other information on results incl. tables
After 24 hours of exposure the total rate of immobilization of daphnia was 100% at nominally 1000 mg/L, 65% at nominally 560 mg/L and 45% at nominally 320 mg/L. No immobilization of daphnia was seen at or below 180 mg/L. After 48 hours of exposure immobilization of all daphnia exposed was seen at nominal concentrations of 560 mg/L and higher. A t nominally 320 mg/L the total incidence of immobility had increased to 70%. A t nominally 180 mg/L, 1 out of totally twenty daphnia exposed had become immobile. Since a total of 10% immobility is accepted in the untreated control, this can be considered as not biologically significant. No immobilization of daphnia was seen at 100 mg/L.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the conditions of the present study C4-DIACETAL did not induce biologically significant acute immobilization of Daphnia magna at or below
180 mg/L after 48 hours of exposure (NOEC) with a 48h-EC50 of 275 mg/l (95% confidence interval between 241 and 316 mg/L). - Executive summary:
Acute Toxicity Study in Daphnia magna with C4 -DIACETAL. Daphnia were exposed for a maximum of 48 hours to a concentration range of 100 to 1000 mg/L forming a geometric progression with a factor of 1.8. The test was performed in duplicate with 10 daphnia per vessel. After 24 hours of exposure the total rate of immobilization of daphnia was 100% at nominally 1000 mg/L, 65% at nominally 560 mg/L and 45% at nominally 320 mg/L. No immobilization of daphnia was seen at or below nominally 180 mg/L. After 48 hours of exposure immobilization of all daphnia exposed was seen at nominal concentrations at and above 560 mg/L. At nominally 320 mg/L the total incidence of immobility had increased to 70%. No biologically significant immobilization of daphnia was seen at 100 and 180 mg/L. Analysis of the samples taken at the start of the final test revealed mean actual concentrations of 81%, 78% and 84% relative to the nominal concentrations o f 100, 320 and 1000 mg/L, respectively. During the period before renewal of the test media (24 hours) the actual concentration remained >80% at all three concentrations sampled.
The 24h-EC50 was 401 mg/L with 95% confidence interval ranging from 324 to 506 mg/L (slope = 5.02). The 48h-EC50 was 275 mg/L with 95% confidence interval ranging from 241 to 316 mg/L (slope = 8.62). Finally, the No Observed Effect Concentration for C4-DIACETAL with respect to mobility of Daphnia magna was found to be 180 mg/L after 48 hours of exposure.
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