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EC number: 203-737-8 | CAS number: 110-12-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- single dose followed by 14-day observation period
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted prior to introduction of Good Laboratory Practices; data from a summary report; number of animals similar to that used in current guideline studies; actual test report not available for review but raw data were reviewed for this entry. Study was conducted by an internal Eastman Kodak Company method developed prior to established guidelines. The results of this study are valid for classification insofar as the conditions of exposure are at least as stringent as modern guidelines. Dose range sufficient to determine actual LD50 value for classification purposes.
Data source
Reference
- Reference Type:
- other: Eastman Kodak Company Summary Report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Four groups of four male rats (age and weights not provided) were administered a single dose of the test material at dose levels of 1000, 2000, 4000, or 8000 mg/kg bw by oral gavage and observed for a period of two weeks. The rats were observed for adverse clinical signs and mortality. Body weights were collected prior to dosing and at termination of the observation period. Gross pathology was performed at study termination.
- GLP compliance:
- no
- Test type:
- other: Study conducted according to an internal Eastman Kodak Company laboratory method.
- Limit test:
- no
Test material
- Reference substance name:
- 5-methyl-2-hexanone
- IUPAC Name:
- 5-methyl-2-hexanone
- Reference substance name:
- 5-methylhexan-2-one
- EC Number:
- 203-737-8
- EC Name:
- 5-methylhexan-2-one
- Cas Number:
- 110-12-3
- Molecular formula:
- C7H14O
- IUPAC Name:
- 5-methylhexan-2-one
- Reference substance name:
- MIAK; Isoamyl methyl ketone
- IUPAC Name:
- MIAK; Isoamyl methyl ketone
- Details on test material:
- -Name of test material as cited in study report: Methyl isoamyl ketone
-Appearance: liquid
-Melting Point: -74 °C
-Boiling Point: 145 °C at 760 mm Hg
-Solubility: 0.5% in water at 20 °C
-Storage conditions: room temperature and humidity
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Each animal received a single dose of the test material by oral gavage.
- Doses:
- 1000, 2000, 4000, or 8000 mg/kg bw
- No. of animals per sex per dose:
- 4 males/dose level
- Control animals:
- no
- Details on study design:
- Four groups of four male rats (age and weights not provided) were administered a single dose of the test material at dose levels of 1000, 2000, 4000, or 8000 mg/kg bw by oral gavage and observed for a period of two weeks. The rats were observed for adverse clinical signs and mortality. Body weights were collected prior to dosing and at termination of the observation period.
- Statistics:
- The LD50 estimate was determined by the geometric mean of the top two dose levels.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 5 657 mg/kg bw
- Remarks on result:
- other: The two highest dose levels (4000 and 8000 mg/kg bw) used in this study were higher than that used for a limit dose in present-day guideline studies.
- Mortality:
- No mortality was noted in the 1000, 2000, or 4000 mg/kg bw dose groups. All rats assigned to the 8000 mg/kg bw dose group died within one day of dosing.
- Clinical signs:
- other: No abnormal clinical signs were evident in the 1000 and 2000 mg/kg bw dose groups. At the 4000 and/or 8000 mg/kg bw dose levels, clinical signs of toxicity included weakness, ataxia, tremors, and prostration.
- Body weight:
- other body weight observations
- Remarks:
- All surviving rats gained weight during the 14-day observation period.
- Gross pathology:
- Not reported
Applicant's summary and conclusion
- Interpretation of results:
- other:
- Remarks:
- EU-GHS criteria not met
- Conclusions:
- Under conditions used in this study, methyl isoamyl ketone was not acutely toxic by the oral route in male rats. The oral LD50 in male rats was 5657 mg/kg bw.
Based on an acute oral LD50 value between 4000 and 8000 mg/kg bw (geometric mean of 5657 mg/kg bw) in male rats, methyl isoamyl ketone is not classified for acute lethality by the oral route under EU-GHS. - Executive summary:
In an acute oral toxicity study, four groups of four male rats were administered a single dose of methyl isoamyl ketone by gavage at dose levels of 1000, 2000, 4000, or 8000 mg/kg bw and observed for mortality and adverse clinical signs for a period of 14 days. No mortality was noted in the 1000, 2000, or 4000 mg/kg bw dose groups. All rats assigned to the 8000 mg/kg bw dose group died within one day of dosing. No abnormal clinical signs were evident in the 1000 and 2000 mg/kg bw dose groups. At the 4000 and/or 8000 mg/kg bw dose levels, clinical signs of toxicity included weakness, ataxia, tremors, and prostration. All rats assigned to the 4000 mg/kg bw dose level recovered. All surviving rats gained weight during the 14-day observation period. The oral LD50 in male rats administered methyl isoamyl ketone is considered to between 4000 and 8000 mg/kg bw, with a geometric mean of 5657 mg/kg bw. Ingestion of large amounts may cause effects on the central nervous system. According to EU-GHS no classification is warranted for 5 -methylhexan-2 -one for acute oral toxicity.
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