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EC number: 610-977-0 | CAS number: 53201-62-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998-05-14 to 1998-07-20
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD study under GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Hydroquinone-bis-p-hydroxybenzoate
- IUPAC Name:
- Hydroquinone-bis-p-hydroxybenzoate
- Details on test material:
- - Name of test material (as cited in study report): Hydroquinone-bis-p-hydroxybenzoate (OH-Dreikerner)
- Physical state: solid
- Analytical purity: >95% (HPLC)
- Impurities (identity and concentrations): as stated in substance data
- Composition of test material, percentage of components: as stated in substance data
- Lot/batch No.: 63B001
- Expiration date of the lot/batch: 2003-02-28
- Stability under test conditions: stable
- Storage condition of test material: in original container, at room temperature, in the dark
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
not applicable
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Sample storage conditions before analysis: in a refrigerator
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Pre experiments were carried out to determine the solubility of the test subtance in water. The substance was dispersed in water.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna (Straus, clone 5)
- Source: Umweltbundesamt, Institut für Wasser, Luft und Bodenhygiene
- Age at study initiation (mean and range, SD): 6-24 hours old
- Method of breeding: similar conditions as in test (pH, main ions, total hardness)
ACCLIMATION
- Acclimation period: for at least 6 hours under the test conditions
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Remarks on exposure duration:
- NOT_SPECIFIED
- Post exposure observation period:
- none
Test conditions
- Hardness:
- 250 mg/l as CaCO3
- Test temperature:
- 20°C
- pH:
- 8.0-8.1
- Dissolved oxygen:
- 9.0 -9.2 mg/L
- Nominal and measured concentrations:
- The analytically determined test substance concentrations in the analysed test medium varied in the range from 93% to 120% of the nominal value (see attached analytical report). In the test medium the test substance was sufficiently stable during the test period of 48 . Therefore all reported biological results are related to the nominal concentration of the test substance.
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, size, headspace, fill volume: glass beakers of 100 ml filled with 50 ml.
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates):2
- No. of vessels per control (replicates):2
OTHER TEST CONDITIONS
- Photoperiod: 18 h light
- Light intensity: 290 - 550 lux
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: reconstituted water
- Alkalinity: 0.8 mmol/l
- Ca/Mg ratio: 4:1
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
Immobilty and mortality after 24 and 48 hours. Immobilty criteria: No efforts to swim within 15 seconds afer agitation. - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- > 100 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 100 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Effect concentrations exceeding solubility of substance in test medium: Due to the low water solubility of the test substance the substance could only be diespersed in water. After 24 and 48 hours a small part of the test substance was lying at the bottom of the glass breakers.
- Results with reference substance (positive control):
- Tested twice a year. The last test is recorded under the IBACON project numer 3160220. The EC50 was calculated to be 0.55 mg/L.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Substance is not toxic to daphnids.
- Executive summary:
The acute toxicity of the test substance Hydroquinone-bis-p-hydroxybenzoate (OH-Dreikerner) to Daphnia magna was determined in a 48 hour static test according to OECD Guidline 202 Part I (1984) and the Commision Directive 92/69/EEC, Annex Part C, C.2 (1992).
A limit test was performed in accordance with the Commision Directive 92/69/EEC to demonstrate that the test substance has no toxic effects on the test animals up to the concentration of nominal 100mg/L. All reported results are related to the nominal concentration of the test substance. During the test period test substance concentrations were measured in the range from 93% to 120% of the nominal value. Under the test conditions the test substance was sufficently stable during the test period of 48 hours.
The 48 -hour NOIEC (highest concentration tested without toxic effects after the exposure period of 48 hours, respectively the 48 -hour EC 0 of Hydroquinone-bis-p-hydroxybenzoate (OH-Dreikerner) to Daphnia magna were determined to be at least 100 mg/L. The NOEC and the EC 0 might even be higher than this concentration, but concentrations in excess of 100 mg/L have not been tested. The 48 -hour EC 50 and EC100 were clearly higher than 100 mg/L. This value could not be quantified due to the absence of toxcicity of Hydroquinone-bis-p-hydroxybenzoate (OH-Dreikerner) up to this concentration.
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