Registration Dossier
Registration Dossier
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EC number: 277-143-2 | CAS number: 72968-50-4 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Citrus aurantium, Rutaceae.
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
For all citrus oils, the in vitro gene mutation study in bacteria (Ames test) was negative.
Short description of key information:
Ames test with bitter orange oil: not genotoxic.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the available information, the substance bitter orange oil does not need to be classified for mutagenicity according to the criteria outlined in Annex I of 1272/2008/EC (CLP/EU-GHS).and Annex VI of 67/548/EEC.
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