Registration Dossier
Registration Dossier
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EC number: 425-430-1 | CAS number: 6746-94-7
Endpoint summary
Administrative data
Description of key information
Skin
In vivo
Rabbit (OECD 404): irritating (Huntingdon Life Sciences Ltd)
In vitro
Actually, there is no information available
Eye
Actually, there is no information available
Respiratory system
Actually, there is no information available.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
There only limited information available for the assessment of the skin and eye irritation potential of Ethynyl cyclopropane.
Skin
The potential of Ethynyl cyclopropane to cause acute dermal irritation or corrosion was assessed in vivo in New Zealand rabbits. In this study the unchanged test material was applied for 4 hours to the shaved skin of 3 animals under occlusive conditions. Based on the limited information available the test substances caused a mean erythema score of 2 and a mean edema score of 1.66 calculated for all animals for the readings at 24, 48 and 72 hours. In addition the findings were not fully reversible at the end of the observation period of 14 days. Interestingly, only slight edema and erythema were observed in rats when exposed for 24 hours to the unchanged test material at a limit dose of 2000 mg/kg under occlusive conditions (OECD 403 guideline study, DuPont Merck, 1997). In this study the transient very slight irritation (Grade 1 erythema with or without Grade 1 oedema) was first notable in eight animals following removal of the dressings, evident in smaller number of animals over the following days and had resolved in all instances within five days of treatment. In guinea pigs the test substance produced also slight edema after topical application when applied undiluted (pretest for skin sensitization study, Huntingdon Life Sciences Ltd., no further data available).
Eye
Actually, there is no information available.
Respiratory system
Actually, there is no information available.
Effects on skin irritation/corrosion: irritating
Justification for classification or non-classification
Skin
Based on the results of the in vivo experiments, the test substance needs to be labelled as “irritating to the skin”, according to the criteria defined by the EU and the GHS system.
Eye
Based on the results of the results of the skin irritation, the test substance is also considered as irritant to the eye and therefore needs to be classified and labelled according to EU and GHS criteria.
Respiratory system
Actually, there is no indication given for a classification according to this endpoint.
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