Poly(oxy-1,2-ethanediyl),α-hydro-ω-hydroxy- Ethane-1,2-diol, ethoxylated

Toxicity to microorganisms

Link to relevant study record(s)

Reference

Endpoint:

toxicity to microorganisms, other

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

experimental data for various test chemicals

Justification for type of information:

experimental data for various test chemicals

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: Refer the principles below

Principles of method if other than guideline:

WoE report is prepared based on toxicity to microorganisms study:
2 and 3 reports

GLP compliance:

no

Analytical monitoring:

no

Vehicle:

no

Test organisms (species):

other: 2: Chilomonas paramaecium 3: Pseudomonas putida

Test type:

static

Water media type:

not specified

Limit test:

no

Total exposure duration:

48 h

Remarks on exposure duration:

3rd study exposure was for 16 hours.

Reference substance (positive control):

no

Key result

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

2 774 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: Decrease in the cell count

Key result

Duration:

16 h

Dose descriptor:

other: TT

Remarks:

thresold toxicity

Effect conc.:

255 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth inhibition

Validity criteria fulfilled:

not specified

Conclusions:

2:The effects of test chemical on the chilomonas paramecium was studied and the median effective concentration was determined to be 2774 mg/L.
3: The effect of the test chemical on their cell multiplication was studied for the 16.0 h and thresold toxicity was determined to be 255 mg/L.

Executive summary:

The weight of evidence was prepared by taking the read across of structurally and functionally similar structure.

The data was published in the peer reviewed journal.

The study outlines the effects of test chemical on the test species chilomonas paramecium. The test was performed for the period of 48 hours in the static exposure conditions. Based on the outcome the median lethal concentration of test chemical was 2774mg/L.

Similar study outlines the effects of test chemical on the test species Pseudomonas putida. The basis of effect was their cell multiplication for the period 16.0 h and threshold toxicity was determined to be 255 mg/L.

Thus based on the outcomes the test chemical is toxicity ranges between 255- 2774 mg/L to various microorganisms.

Description of key information

The study outlines the effects of test chemical on the test species chilomonas paramecium. The test was performed for the period of 48 hours in the static exposure conditions. Based on the outcome the median lethal concentration of test chemical was 2774mg/L.

 

Key value for chemical safety assessment

EC50 for microorganisms:

2 774 mg/L

Additional information

The weight of evidence was prepared by taking the read across of structurally and functionally similar structure.

The data was published in the peer reviewed journal.

The study outlines the effects of test chemical on the test species chilomonas paramecium. The test was performed for the period of 48 hours in the static exposure conditions. Based on the outcome the median lethal concentration of test chemical was 2774mg/L.

Similar study outlines the effects of test chemical on the test species Pseudomonas putida. The basis of effect was their cell multiplication for the period 16.0 h and threshold toxicity was determined to be 255 mg/L.

Thus based on the outcomes the test chemical is toxicity ranges between 255- 2774 mg/L to various microorganisms.