Registration Dossier
Registration Dossier
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EC number: 277-901-2 | CAS number: 74509-79-8
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 5-[ethyl(2-hydroxyethyl)amino]pentan-2-one
- EC Number:
- 277-901-2
- EC Name:
- 5-[ethyl(2-hydroxyethyl)amino]pentan-2-one
- Cas Number:
- 74509-79-8
- Molecular formula:
- C9H19NO2
- IUPAC Name:
- 5-[ethyl(2-hydroxyethyl)amino]pentan-2-one
- Test material form:
- liquid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- The Daphnia introduced in the test were taken from ibacon's in-house laboratory culture.
Study design
- Test type:
- static
- Water media type:
- freshwater
Test conditions
- Test temperature:
- 20 to 21 °C at test start
20 °C at test end - pH:
- 7.6 to 9.0 at test start
8.0 to 8.3 at test end - Dissolved oxygen:
- 8.7 to 9.1 mg/L at test start
9.3 to 9.6 mg/L at test end - Nominal and measured concentrations:
- 100, 45.5, 20.7, 9.4 and 4.3 mg test item/L and a control
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 45.5 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mortality
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mortality
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mortality
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The toxic effect of the test item HYDROXY NOVOL KETONE to Daphnia magna was assessed in a static concentration-response test. The 48-hour NOEC was determined to be 45.5 mg test item/L. The 48-hour LOEC was determined to be 100 mg test item/L and the 48-hour EC50 value was calculated to be 100 mg test item/L. All values refer to nominal concentrations.
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