Registration Dossier
Registration Dossier
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EC number: 444-110-0 | CAS number: 16510-27-3
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- GLP compliance:
- yes
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- -
- EC Number:
- 444-110-0
- EC Name:
- -
- Cas Number:
- 16510-27-3
- Molecular formula:
- C11H14O
- IUPAC Name:
- 1-(cyclopropylmethyl)-4-methoxybenzene
- Details on test material:
- Batch Number LDP200015
Purity 99.1%
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
Study design: in vivo (LLNA)
- Vehicle:
- other: ethanol:water, 7:3 (v/v)
- Concentration:
- 0.1%, 1%, 10%, (w/v) in ethanol:water 7:3 (v/v) and 100% Undiluted
- No. of animals per dose:
- 4 females per group
4 groups of animal
Topical application to the dorsal suface of each ear lobe (left and right)
Results and discussion
In vivo (LLNA)
Results
- Parameter:
- SI
- Remarks on result:
- other: Group 2 (0.1%) - SI=0.5 Group 3 (1%) - SI=1.1 Group 4 (10%) - SI = 2.8 Group 5 (100% undiluted) - SI =5.5%
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- An EC3 value of 16.7% (w/v) was derived.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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