Registration Dossier
Registration Dossier
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EC number: 457-940-3 | CAS number: 183065-68-1
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September/October 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to OECD and GLP guidelines
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 2000/32/EG, B.13, B.14
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 4-bromo-2,6-difluorobenzoic acid
- EC Number:
- 457-940-3
- EC Name:
- 4-bromo-2,6-difluorobenzoic acid
- Cas Number:
- 183065-68-1
- Molecular formula:
- Hill formula: C7H3BrF2O2 CAS formula: C7H3BrF2O2
- IUPAC Name:
- 4-bromo-2,6-difluorobenzoic acid
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- bacteria, other: sat TA 98, 100, 102, 1535, 1537; esc WP2 uvrA
- Metabolic activation system:
- Arochlor-induced rat livers S-9 mix
- Test concentrations with justification for top dose:
- Concentration range in the main test (with metabolic activation): 5 ... 5000 µg/plate
Concentration range in the main test (without metabolic activation): 5 ... 5000 µg/plate - Vehicle / solvent:
- Solvent: DMSO
- Details on test system and experimental conditions:
- Concentration of the test substance resulting in precipitation: 1580 µg/plate
Results and discussion
Test resultsopen allclose all
- Species / strain:
- other: as specified above
- Metabolic activation:
- with
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- ( 5000 µg/plate)
- Species / strain:
- other: as specified above
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- ( 5000 µg/plate)
- Remarks on result:
- other: other: main test
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative with metabolic activation
negative without metabolic activation - Executive summary:
The mutagenic potential of 4-Bromo-2,6-difluorobenzoic acid was tested according to OECD 471 with and without metaboic activation system. The study showed no increased mutation frequencies after incubation with 4-Bromo-2,6-difluorobenzoic acid with and without metabolic activation. Consequently, 4-Bromo-2,6-difluorobenzoic acid is not mutagenic in this test system.
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