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EC number: 202-767-9 | CAS number: 99-57-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer reviewed journals
Data source
Reference
- Reference Type:
- publication
- Title:
- Assessment of the Acute Toxicity and Potential Irritancy of Hair Dye Constituents
- Author:
- G. K. LLOYD, M. P. LIGGETT, S. R. KYNOCH and R. E. DAVIES
- Year:
- 1 977
- Bibliographic source:
- Fd Cosmet. Toxicol. Vol. 15, pp. 607-610; 1977.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Consumer Product Safety Commission of the USA (Code of Federal Regulations, Title 16, Sec. 1500.41)
- Principles of method if other than guideline:
- To assess the dermal irritancy potential of the test chemical in rabbits
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-amino-4-nitrophenol
- EC Number:
- 202-767-9
- EC Name:
- 2-amino-4-nitrophenol
- Cas Number:
- 99-57-0
- Molecular formula:
- C6H6N2O3
- IUPAC Name:
- 2-amino-4-nitrophenol
- Details on test material:
- - Name of test material (as cited in study report): 2-amino-4-nitrophenol
- Substance type: Organic
- Physical state: solid
- InChI: 1S/C6H6N2O3/c7-5-3-4(8(10)11)1-2-6(5)9/h1-3,9H,7H2
- Smiles: Nc1cc(ccc1O)[N+](=O)[O-]
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- The albino rabbits used for the assessment.
Test system
- Type of coverage:
- other: intact and abraded skin
- Preparation of test site:
- other: intact and abraded
- Vehicle:
- other: Suspension in 0.5% aqueous gum tragacanth, containing 0.05% Na2SO3.
- Controls:
- not specified
- Amount / concentration applied:
- 2.5% (w/v) Suspension in 0.5% aqueous gum tragacanth, containing 0.05% Na2SO3.
- Duration of treatment / exposure:
- Single exposure
- Observation period:
- 72 hrs
- Number of animals:
- 3
- Details on study design:
- SCORING SYSTEM: Based on the definition of skin irritation given in the (Code of Federal Regulations, Title 16, Sec. 1500.41).
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- None of the animals treated showed any response to treatment
Any other information on results incl. tables
Table: Results of the skin and eye irritancy studies on rabbits
Compound |
Skin Irritation (Primary Irritation Index) |
Eye Irritation ** |
99 -57 -0 |
0 |
± |
**Categorized as + or - according to whether extrapolation of the result would be expected to give a positive or negative in the Code of Federal Regulations, Test for Eye Irritants (Title 16, Sec. 1500.42).
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- None of the rabbits treated with the test chemical showed any signs of irritation during the 72 hours observation period. The Primary Irritation Index was 0.0.
Based on the scores and observations, the test chemical was considered to be not irritating to albino New Zealand White rabbit skin. - Executive summary:
The dermal irritancy potential of the test chemical was evaluated in rabbits. The study was conducted as per Consumer Product Safety Commission of the USA (Code of Federal Regulations, Title 16, Sec. 1500.41).2.5% (w/v) Suspension of the test chemical in 0.5% aqueous gum tragacanth, containing 0.05% Na2SO3was applied to the intact and abraded skin of 3 New Zealand White albino rabbits. The rabbits were observed for signs of irritation till 72 hours and the reactions were scored based on the definition of skin irritation given in the Code of Federal Regulations, Title 16, Sec.1500.41.
None of the rabbits treated with the test chemical showed any signs of irritation during the 72 hours observation period. The Primary Irritation Index was 0.0.
Based on the scores and observations, the test chemical was considered to be not irritating to albino New Zealand White rabbit skin.
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