Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 442-600-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
One oral and two dermal studies were performed to examine the acute toxicity of H7134. According to the results the test material is not acutely toxic after either oral ingestion or contact with the skin.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
One acute oral study and two acute dermal studies are available with HiTEC 7134, which fully satisfy the requirements of REACH Regulation for this endpoint. An inhalation study was not performed taking into consideration the very low vapour pressure of the substance, as well as its very high viscosity.
In the oral assessment (Johnson IR (2011a)), a group of five male and five female Alpk: APfSD (Wistar derived) rats received a single oral dose of 2000 mg HiTEC 7134/kg bw and were observed daily for the following 14 days for any signs of toxicity. There were no signs of evident toxicity, and most of the animals showed an overall weight gain during the study. No compound-related abnormalities were detected at post mortem examination. The highest fixed dose of H7134 administered in this test did not cause any lethality, and thus, the oral LD50 is higher than 2000 mg/kg bw.
In one of the dermal toxicity assessments, which was considered to be the key study, five male and five female Alpk: APfSD rats were dermally exposed to 2000 mg/kg bw of HiTEC 7134 for 24h (Johnson IR (2001b)). The study was performed according to the OECD Guideline 402. No signs of toxicity were detected, besides slight skin irritation, which totally resolved by the end of the study. No mortality was seen, and hence, the dermal LD50 is higher than 2000 mg H7134/kg bw.
In the second acute dermal toxicity study, one group of ten New Zealand White rabbits (five males and five females) was used. One dermal semi-occluded patch of HiTEC 7134 at 2000 mg/kg, was applied to the clipped dorsal skin of each animal (Mallory VT (1995)). The patches were removed after 24 hours, and the animals were observed for 14 days. No signs of toxicity were detected, besides skin irritation (erythema, edema, fissuring and sloughing) at the application site. None of the animals died during the study; the estimated acute dermal LD50 was determined to be greater than 2000 mg/kg bw.
Justification for selection of acute toxicity – inhalation endpoint
There is no available acute toxicity study using the inhalation route. Due to the physical-chemical properties of the substance, generation of vapors or aerosols is unfeasible; thus, no inhalation studies (acute or repeated-dose) were performed. The log Kow is above 6.4, indicating that the substance is highly lipophilic and viscous, and the vapor pressure is very low, 0.00002 Pa. The test substance is clearly not volatile.
Justification for classification or non-classification
Both oral and dermal LD50s are higher than 2000 mg/kg bw, on the basis of the aforementioned results. HiTEC 7134 did not exert any toxic effects in all three studies, besides skin irritation in the dermal studies. It shall not be classified as acutely toxic after oral ingestion or skin contact, according to the criteria laid down in Regulation (EC) 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.