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EC number: 407-920-5 | CAS number: 6390-69-8 CA 16-178
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study (GLP)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- February 24, 1987
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3,3',5,5'-tetra-tert-butylbiphenyl-2,2'-diol
- EC Number:
- 407-920-5
- EC Name:
- 3,3',5,5'-tetra-tert-butylbiphenyl-2,2'-diol
- Cas Number:
- 6390-69-8
- Molecular formula:
- C28 H42 O2
- IUPAC Name:
- 3,3',5,5'-tetra-tert-butyl-[1,1'-biphenyl]-2,2'-diol
- Details on test material:
- - Name of test material (as cited in study report): generic name CA 16-178
- Physical state: powder
- Analytical purity: 97.7% (not specified in the study [Lab. sample], transfered from 28d study [BASF SE [Ciba-Geigy Ltd/884619]], with same Lot/batch)
- Lot/batch No.: A 88103 / Z 1572R
- Storage condition of test material: room temperature
- Other: gloves and face masks as safety precautions
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: albino rats
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: young adult albino rats (Tif; RAIf (SPF)) bred and raised on the premises from CIBA-GEIGY Limited, Animal Production, 4332 Stein / Switzerland
- Age at study initiation: 7-8 weeks
- Weight at study initiation: 211-254 g
- Housing: individually in Macrolon cages type 3
- Diet (e.g. ad libitum): rat chow (NAFAG 890 Tox, NAFAG, Gossau/SG, Switzerland); ad libitum
- Water (e.g. ad libitum): drinking water; ad libitum
- Acclimation period: at least 5 days before administration
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22±2°C
- Humidity (%): 55±10%
- Air changes (per hr): approx. 15 air changes per hour
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- arachis oil
- Remarks:
- Ol. arachidis Ph. H, VI
- Details on dermal exposure:
- TEST SITE
- Area of exposure: approx. 24 hours before treatment an area on the back of the rat was shaved with an electric clipper
- % coverage: at least 10% of the body surface
- Type of wrap if used: covered with a gauze-lined semiocclusive dressing fastened around the trunk with an adhesive elastic bandage
REMOVAL OF TEST SUBSTANCE
- Washing (if done): the dressing was removed and the skin was cleaned with lukewarm water
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2000 mg/kg bw test substance
VEHICLE
- Concentration (if solution): 4 ml/kg bw
- Concentration (if solution): 500 mg test substance/ml - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: mortality daily (a.m. and p.m. on working days; a.m. on weekend days); signs and symptoms daily; body weight at start and on days 7 and 14. The skin reaction was appraised repeatedly.
- Necropsy of survivors performed: yes; the animals were submitted to a gross necropsy at the end of the observation period. - Statistics:
- From the body weights, the group means and their standard deviations were calculated.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000
- Based on:
- test mat.
- Remarks on result:
- other: No mortality occurred at this unique dose level; no specific signs of toxicity observed
- Mortality:
- No mortality occurred in this study.
- Clinical signs:
- other: Piloerection (up to day 5), abnormal body positions (hunched posture up to day 4 and ventral recumbency up to day 1), and dyspnea (up to day 2) were seen, being common symptoms in acute dermal tests. Additionally, erythema at the application site was obse
- Gross pathology:
- At autopsy, no deviations from normal morphology were found.
Any other information on results incl. tables
Table 1: Mean body weight and standard deviation (g)
|
At administration day |
At day 7 |
At day 14 |
Males (2000 mg/kg bw) |
248 ± 5.6 |
281 ± 12.1 |
319 ± 14.9 |
Females (2000 mg/kg bw) |
221 ± 8.5 |
228 ± 6.0 |
245 ± 13.5 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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