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Diss Factsheets
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EC number: 226-501-6 | CAS number: 5413-60-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Maximization tests
- GLP compliance:
- not specified
- Type of study:
- other: Maximization tests
- Species:
- human
- Strain:
- not specified
- Sex:
- not specified
- Route:
- other: no data
- Vehicle:
- petrolatum
- Concentration / amount:
- 20% (13,800 lg/cm2) tricyclodecenyl acetate and 8% (5520 micro.gm./cm2) tricyclodecenyl acetate
- Route:
- other: occlusion
- Vehicle:
- petrolatum
- Concentration / amount:
- 20% (13,800 lg/cm2) tricyclodecenyl acetate and 8% (5520 micro.gm./cm2) tricyclodecenyl acetate
- No. of animals per dose:
- 26 volunteers and 21 volunteers
- Details on study design:
- Test material was applied in petrolatum under occlusion to the forearms for a total of five alternate-day 48-h periods. Each application was preceded by a 24-h occlusive treatment of the patch sites with 5% aqueous sodium lauryl sulfate (SLS). Following a 10- to 14-day rest period, challenge patches were applied under occlusion to fresh sites for 48 h.Challenge applications were preceded by 30 min applications of 2–5% SLS under occlusion on the left side and no pretreatment on the right side.
- Challenge controls:
- Following a 10- to 14-day rest period, challenge patches were applied under occlusion to fresh sites for 48 h. Challenge applications were preceded
by 30 min applications of 2–5% SLS under occlusion on the left side and no pretreatment on the right side. Challenge sites were evaluated at removal of the patches and 24 h later. - Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 20
- No. with + reactions:
- 0
- Total no. in group:
- 26
- Clinical observations:
- There was no evidence of contact sensitization
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: 20. No with. + reactions: 0.0. Total no. in groups: 26.0. Clinical observations: There was no evidence of contact sensitization.
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 8
- No. with + reactions:
- 0
- Total no. in group:
- 21
- Clinical observations:
- There was no evidence of contact sensitization
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: 8. No with. + reactions: 0.0. Total no. in groups: 21.0. Clinical observations: There was no evidence of contact sensitization.
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In two separate maximization tests involving 26 and 21 volunteers, there was no evidence of contact sensitization to 20% (13,800 lg/cm2)or 8% (5520 lg/cm2) tricyclodecenyl acetate(3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate), respectively.
- Executive summary:
In two separate maximization tests involving 26 and 21 volunteers, there was no evidence of contact sensitization to 20% (13,800 lg/cm2)or 8% (5520 lg/cm2) tricyclodecenyl acetate(3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate), respectively.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
- Migrated from Short description of key information:
In two separate maximization tests involving 26 and 21 volunteers, there was no evidence of contact sensitization to 20% (13,800 lg/cm2)or 8% (5520 lg/cm2) tricyclodecenyl acetate(3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate), respectively.
Justification for classification or non-classification
3a,4,5,6,7,7a-hexahydro-4,7-methanoinden-6-yl acetate will not be classified as per the C & L criteria set by EU.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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