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EC number: 222-315-4 | CAS number: 3423-28-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2001
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- 8-isopropyl-8-azabicyclo[3.2.1]octan-3-one
- EC Number:
- 222-315-4
- EC Name:
- 8-isopropyl-8-azabicyclo[3.2.1]octan-3-one
- Cas Number:
- 3423-28-7
- Molecular formula:
- C10H17NO
- IUPAC Name:
- 8-isopropyl-8-azabicyclo[3.2.1]octan-3-one
- Test material form:
- other: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 200 mg/kg and 2000 mg/kg
- No. of animals per sex per dose:
- 3
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- Considering the reported data of this toxicity test it can be stated that the test item N-Isopropylnortropinon has acute toxic characteristics.
The LDso was determined to be between 300 and 500 mglkg bw. - Executive summary:
The acute toxic class method was performed with N-Isopropylnortropinon. It is the principle of the acute toxic class method that, based on a stepwise procedure with the use of a minimum number of animals per step, sufficient information is obtained on the acute toxicity of the test item to enable its classification. In the first step the test item N-Isopropylnortropinon was given in a dose of 200 mg/kg body weight to a group of 3 male rats (HsdBr1: WH Wistar) in a single exposure via oral gavage. In a second step the test item was given to a group of 3 female rats (HsdBr1:WH Wistar) in a single exposure via oral gavage. The dosage of 200 mg/kg bw caused neither compound-related mortality in the three male nor in the three female animals within 14 day p. appl.. A careful clinical examination was made once a day. At the end of the observation period the animals were sacrificed and necropsy was carried out to record gross pathological changes. No clinical signs of toxicity were observed throughout the observation period. Beside acute injection of blood vessels in the abdominal region, which is due to the euthanasia injection-no special gross pathological changes were found in animals of step 1 and step 2. According to the acute toxic class method regime, in a third step the test item N-Isopropylnortropinon was given to a further group of male animals in a dose of 2000 mg/kg bw. . The dosage of 2000 mg/kg bw caused peracute compound-related mortality in two male animals. Animal No. 1 was dead within 1 minute p.appl. and animal No. 2 was dead 10 minutes p. appl. Both animals showed tremor, convulsion, respiratory distress and prone position. No special gross pathological changes were found in the two males of step 3. Due to animal welfare reasons (severe signs of morbidity, resulting in peracute death), a third application of 2000 mg/kg bw was not performed and a dosage of 2000 mg/kg bw was stated to cause 100% compound-related mortality in this group. According to the acute toxic class method regime no further testing was required. According to the results obtained the LD50 was determined to be between 300 and 500 mg/kg bw.
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