Registration Dossier
Registration Dossier
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EC number: 226-736-4 | CAS number: 5460-09-3
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary information taken from OECD SIDS document. Original report given as of high quality, but not available for review.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Initial Targeting Assessment Report For SIAM 31 Paris, France, 19-22 October 2010
- Author:
- OECD
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- yes
- Type of assay:
- bacterial forward mutation assay
Test material
- Reference substance name:
- Sodium hydrogen 4-amino-5-hydroxynaphthalene-2,7-disulphonate
- EC Number:
- 226-736-4
- EC Name:
- Sodium hydrogen 4-amino-5-hydroxynaphthalene-2,7-disulphonate
- Cas Number:
- 5460-09-3
- Molecular formula:
- C10H9NO7S2.Na
- IUPAC Name:
- sodium hydrogen 4-amino-5-hydroxynaphthalene-2,7-disulfonate
Constituent 1
Method
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Species / strain / cell type:
- E. coli WP2 uvr A
- Metabolic activation:
- with and without
- Test concentrations with justification for top dose:
- 0, 312.5, 625, 1250, 2500, 5000 μg/plate
Results and discussion
Test resultsopen allclose all
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Genotoxicity:
- negative
- Species / strain:
- E. coli WP2 uvr A
- Genotoxicity:
- negative
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
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