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Diss Factsheets
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EC number: 425-220-8 | CAS number: 5945-33-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable, well-documented publication and study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Comparative metabolism and toxicokinetics of 14C-Resorcinol Bis-Diphenylphosphate (RDP) in the rat, mouse, and monkey
- Author:
- Freudenthal RI., McDonald LJ., Johnson JV., McCormick DL. and Henrich RT
- Year:
- 2 000
- Bibliographic source:
- International Journal of Toxicology 19: 233-242
Materials and methods
- Objective of study:
- absorption
- distribution
- toxicokinetics
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 417 (Toxicokinetics)
Test material
- Reference substance name:
- Tetraphenyl m-phenylene bis(phosphate)
- EC Number:
- 260-830-6
- EC Name:
- Tetraphenyl m-phenylene bis(phosphate)
- Cas Number:
- 57583-54-7
- IUPAC Name:
- tetraphenyl 1,3-phenylene bis(phosphate)
- Reference substance name:
- 125997-21-9
- EC Number:
- 603-113-9
- Cas Number:
- 125997-21-9
- IUPAC Name:
- 125997-21-9
- Details on test material:
- Nonradiolabeled RDP was obtained from Akzo NobelChemicals (Dobbs Ferry, NY).14C-RDP was purchased from DuPont/New England Nuclear (Boston, MA). It had a specific cactivity of 48.6 mCi/mmole. The radiolabeled RDP was repurified prior to use, to achieve a minimum radiochemical purity of 99.0%.
Constituent 1
Constituent 2
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- The RDP was present in significant amounts only in the feces of animals exposed by inhalation or gavage; this appears to reflect unabsorbed ingested material. Dermal absorption of RDP in the rat was relatively low 83% and 20% absorption by the oral and dermal route, respectively.
- Details on distribution in tissues:
- The brain, mesenteric fat, kidneys, liver, lungs, testes/ovaries, and spleen were removed, weighed, and homogenized. Measured aliquots of the tissue homogenates, and of the residual carcass, were solubilized and then the radioactivity therein was quantified by scintillation counting.
- Details on excretion:
- Significant quantitative differences were observed for the radioactivity eliminated in the feces, the primary route of excretion. The largest fraction of the administered dose eliminated in the feces was seen in rats that received RDP via oral dosing. In these animals, approximately 80% of the dose was excreted during the first day after administration. Fecal excretion of radiolabel by rats exposed to RDP by other routes was considerably slower. Animals that received RDP by the inhalation, intravenous, and dermal routes had 60%, 48%, and 32% of the administered dose in their feces. Regardless of the route of exposure, fecal excretion was at least threefold greater than urinary excretion of total radiolabel. The expired air was a minor route of excretion, regardless of route of dosing. A comparison of the parameters obtained after intravenous injection of RDP to primates and rats showed similar concentration versus time profiles, and both species demonstrated two-compartment toxicokinetics. In both species, the primary route of excretion was via the feces. After dermal exposure, there was significantly less absorption by the primate as compared to the rat.
Toxicokinetic parametersopen allclose all
- Test no.:
- #1
- Toxicokinetic parameters:
- AUC: 1895.0 ± 213 µg equiv × h/mL (monkey i.v.)
- Test no.:
- #2
- Toxicokinetic parameters:
- Cmax:
- Test no.:
- #3
- Toxicokinetic parameters:
- Tmax:
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.