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EC number: 936-023-6 | CAS number: 950782-86-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 850.1035 (Mysid Acute Toxicity Test)
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: A primary stock solution was prepared at a nominal concentration of 50 mg a.i./mL by dissolving a calculated amount of AE 1170437 into dimethyl formamide (DMF). The stock solution was mixed for approximately 30 seconds of sonication followed by inversion, and appeared clear and tan in color.
Aliquots of the 50 mg a.i./mL stock solution were proportionally diluted with DMF to prepare secondary stock solutions.
- Chemical name of vehicle: Dimethyl formamide (DMF) - Test organisms (species):
- Americamysis bahia (previous name: Mysidopsis bahia)
- Details on test organisms:
- TEST ORGANISM
- Common name: saltwater mysid
- Source: Cultures maintained by Wildlife International, Ltd., Easton, Maryland. Identification of the species was verified by the supplier of the original culture stock. The original culture was received on April 5, 2007 from Aquatic Bio Systems, Fort Collins, CO 80524.
- Age at study initiation: <24 hours old
- Feeding during test
- Food type: live brine shrimp Artemia nauplii
- Frequency: daily
ACCLIMATION
- Acclimation conditions (same as test or not): Adult mysids were held in water from the same source and at approximately the same
temperature as used during the test. - Test type:
- static
- Water media type:
- saltwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Test temperature:
- 24.0 to 25.3°C
- pH:
- 7.8 to 8.2
- Dissolved oxygen:
- 5.9 to 6.8 mg/L (≥80% of saturation)
- Salinity:
- 19-20 parts per thousand (‰)
- Nominal and measured concentrations:
- Nominal concentrations: 0.31, 0.63, 1.3, 2.5 and 5.0 mg a.i./L
Measured concentrations: 0.26, 0.52, 1.1, 1.9 and 4.0 mg a.i./L, representing 84, 83, 85, 76 and 80% of nominal concentrations, respectively. - Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, size, headspace, fill volume: 2-L glass beakers containing approximately 1.5 L of test solution.
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
- No. of vessels per vehicle control (replicates): 2
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: according to guideline (The water used for culturing and testing was natural seawater collected at Indian River Inlet, Delaware that was filtered and diluted to a salinity of approximately 20‰ with well water.)
OTHER TEST CONDITIONS
- Photoperiod: 16 hours of light and 8 hours of darkness
- Light intensity: 205 lux
EFFECT PARAMETERS MEASURED: Observations of mortality and other signs of toxicity were made approximately 4, 24, 48, 72 and 96 hours after test initiation. - Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 1.5 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 1.1 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 850.1010 (Aquatic Invertebrate Acute Toxicity Test, Freshwater Daphnids)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: FIFRA 72-2
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: Prior to the exposure numerous solutions were prepared, both with and without the use of a solvent stock, in an effort to determine the functional solubility of AE 1170437 in waters used for aquatic testing. Solutions prepared without a solvent were not soluble (noted visually). After
working with various stock solutions the limit of solubility in dilution water was determined to be approximately 10 mg a.i./L using a solvent load of 0.5 ml/L. The test material did not go into solution at 10 mg a.i./L at solvent loads below 0.5 ml/L.
- Controls: yes
- Chemical name of vehicle: Acetone - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Waterflea
- Source: one breeding; original source was Aquatic Biosystems Inc., Fort Collins, CO
- Age at study initiation: < 24 hours old at initiation - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 172 to 178 mg/L
- Test temperature:
- 20 ± 1.0 °C
- pH:
- 8.1 to 8.4
- Dissolved oxygen:
- 7.9 to 8.4 mg/L (87 to 92 % saturation)
- Nominal and measured concentrations:
- Nominal Test Concentrations: Control, Solvent Control, 0.63, 1.25, 2.5, 5.0 and 10 mg a.i./L
Mean Measured Test Concentrations: Control (<0.06), Solvent Control (<0.06), 0.62, 1.23, 2.54, 4.86 and 9.88 mg a.i./L - Details on test conditions:
- TEST SYSTEM
- Test vessel: 250-mL borosilicate glass beakers
- Fill volume: Approximately 200 ml
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- No. of vessels per vehicle control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: according to guideline
OTHER TEST CONDITIONS
- Adjustment of pH: No
- Photoperiod: 16 hours light, 8 hours dark
- Light intensity: 40 - 70 footcandles, Approximately 430 - 750 lux
EFFECT PARAMETERS MEASURED: Immobilization and sublethal behavioral effects - Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 9.88 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Remarks on result:
- other: (practical limit of solubility in test water)
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 4.86 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 9.88 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
Referenceopen allclose all
Saltwater mysids, Americamysis bahia, were exposed under static conditions for 96 hours to five mean measured concentrations of AE 1170437 ranging from 0.26 to 4.0 mg a.i./L. The 96-hour LC50 value was 1.5 mg a.i./L, with conservative 95% confidence limits of 1.1 and 1.9 mg a.i./L. The nomortality concentration and NOEC were 1.1 mg a.i./L.
Results:
Mean Measured |
|
|
|
4 Hours |
24 Hours |
48 Hours |
72 Hours |
96 Hours |
Cumulative Percent Mortality |
||||
Concentration (mg a.i./L) |
Replicat e |
No. Exposed |
No. Dead1 |
Obs.2 |
No. Dead1Obs.2 |
No. Dead1Obs.2 |
No. Dead1Obs.2 |
No. Dead1Obs.2 |
|||||
Negative Control |
A |
10 |
0 |
10 AN |
0 |
10 AN |
0 |
10 AN |
0 |
10 AN |
0 |
10 AN |
0 |
|
B |
10 |
0 |
10 AN |
0 |
10 AN |
0 |
10 AN |
0 |
10 AN |
0 |
10 AN |
|
Solvent Control |
A |
10 |
0 |
10 AN |
0 |
10 AN |
0 |
10 AN |
0 |
10 AN |
0 |
10 AN |
0 |
|
B |
10 |
0 |
10 AN |
0 |
10 AN |
0 |
10 AN |
0 |
10 AN |
0 |
10 AN |
|
0.26 |
A |
10 |
0 |
10 AN |
0 |
10 AN |
0 |
10 AN |
0 |
10 AN |
0 |
10 AN |
5 |
|
B |
10 |
0 |
10 AN |
0 |
10 AN |
1 |
9 AN |
1 |
9 AN |
1 |
9 AN |
|
0.52 |
A |
10 |
0 |
10 AN |
0 |
10 AN |
0 |
10 AN |
0 |
10 AN |
0 |
10 AN |
0 |
|
B |
10 |
0 |
10 AN |
0 |
10 AN |
0 |
10 AN |
0 |
10 AN |
0 |
10 AN |
|
1.1 |
A |
10 |
0 |
10 AN |
0 |
10 AN |
0 |
10 AN |
0 |
10 AN |
0 |
10 AN |
0 |
|
B |
10 |
0 |
10 AN |
0 |
10 AN |
0 |
10 AN |
0 |
10 AN |
0 |
10 AN |
|
1.9 |
A |
10 |
0 |
9 AN; 1 A |
1 |
2 AN; 4 A; 3 E |
5 |
5 E |
7 |
3 E |
8 |
2 E |
90 |
|
B |
10 |
0 |
6 AN; 4 A |
0 |
3 AN; 2 A; 4 E; 1 C |
1 |
9 E |
7 |
3 E |
10 |
- |
|
4.0 |
A |
10 |
1 |
4 E; 5 C |
10 |
- |
- |
- |
- |
- |
- |
- |
100 |
|
B |
10 |
0 |
10 E |
10 |
- |
- |
- |
- |
- |
- |
- |
|
Results:
Sublethal Observations |
|
|
Frequency |
Mean Measured Test Concentration (mg a.i./L) |
(maximum observed during scheduled observation events) |
Control |
0 |
Solvent Control |
0 |
0.62 |
0 |
1.23 |
0 |
2.54 |
0 |
4.86 |
0 |
9.88 |
16 |
|
|
Immobilization |
|
Mean Measured Test Concentration (mg a.i./L) |
Percent Immobilized at 48-Hours |
Control |
0% |
Solvent Control |
0% |
0.62 |
0% |
1.23 |
0% |
2.54 |
0% |
4.86 |
0% |
9.88 |
35% |
Immobilization included organisms that were dead. |
CONCLUSION |
|
Based on immobilizations: |
|
48 Hour NOEC |
4.86 mg a.i./L |
48 Hour LOEC |
9.88 mg a.i./L |
48 Hour EC50 |
>9.88 mg a.i./L (practical limit of solubility in test water) |
Description of key information
The test substance is toxic to saltwater invertebrates but shows a lower toxicity to freshwater invertebrates.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 9.88 mg/L
Marine water invertebrates
Marine water invertebrates
- Effect concentration:
- 1.5 mg/L
Additional information
Three studies with aquatic invertebrates are available, one with a freshwater and two with a saltwater organism. The short term test with Daphnia magna according to OECD 202 revealed an 48-hour EC50 in Daphnia magna greater than 9.88 mg /L test item (practical limit of solubility). The NOEC was 4.86 mg / a.i. L. Saltwater mysids, Americamysis bahia, were exposed under static conditions for 96 hours and the LC50 was 1.5 mg a.i./L. The NOEC was 1.1 mg a.i./L.
Eastern oysters (Crassostrea virginica) were exposed under flow-through conditions for 96 hours to six mean measured concentrations of the test substance ranging from 0.062 to 1.8 mg a.i./L. The test was conducted at concentrations near the functional limit of solubility of the test substance in a saltwater system. There were no mortalities or clinical signs of toxicity observed at any concentration tested. Based on inhibition of shell deposition, the 96-hour EC50 value was 1.0 mg a.i./L, with a 95% confidence interval of 0.71 to 1.2 mg a.i./L. The NOEC was determined to be 0.47 mg a.i./L.
The test substance is toxic to saltwater invertebrates but shows a lower toxicity to freshwater invertebrates.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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