Reaction mass of 2-hexadecyl-N-(2-hydroxyethyl)-3-oxoicosanamide, 2-hexadecyl-N-(2-hydroxyethyl)-3-oxo-, N-(2-hydroxyethyl)-3-oxo-2-tetradecylicosanamide and N-(2-hydroxyethyl)-3-oxo-2-tetradecyloctadecanamide.

Partition coefficient

Administrative data

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

The study was conducted betwenn May and August 2012

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of relevant results

Cross-reference

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2012

Report date:

2012

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: The determination of Partition Coefficient (n-octanol/water) was carried out using the Estimation method modified from OECD Guideline 105

Deviations:

no

Principles of method if other than guideline:

The water or n-octanol solubility of a test substance is specified by the saturation mass concentration of the substance in water or n-octanol at a given temperature and is expressed in mg/L. The partition coefficient (n-octaol/water), Pow, was calculated from the solubilities of the test substance in the pure solvents:

The determination of Partition Coefficient (n-octanol/water) was carried out using the Estimation method modified from OECD Guideline 105 (Water solubility) and is only suitable for test substance.

GLP compliance:

not specified

Type of method:

other: estimation method

Partition coefficient type:

octanol-water

Test material

Test material information

Constituent 1

Reference substance name:

PC-9S

IUPAC Name:

PC-9S

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Details on test material:

Sample name: PC-9S
The test material is an off-white solid at room temperature.

Study design

Analytical method:

other: GPC

Results and discussion

Partition coefficient

Type:

log Pow

Partition coefficient:

6.04

Temp.:

30 °C

Remarks on result:

other: pH range was not stated in report

Details on results:

Here are the results of the prelim test:
Approximate solubility in n-octanol : < 30 000 g/L
Solubility in water : 0.02 g/L
Approximate Pow : 1 500 000
Log10 Pow : < 6.18

Applicant's summary and conclusion

Conclusions:

The partition coefficient (n-octanol / water), Pow, calculated as a quotient of the n-octanol solubility and the water solubility of sample, was determined to be 1 096 772 (Log10 Pow = 6.04)

Executive summary:

The determination of Partition Coefficient (n-octanol/water) was carried out using the Estimation method modified from OECD Guideline 105 (Water solubility) and is only suitable for test substance. The partition coefficient (n-octanol / water), Pow, calculated as a quotient of the n-octanol solubility and the water solubility of sample, was determined to be 1 096 772 (Log10 Pow = 6.04)