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EC number: 202-874-0 | CAS number: 100-64-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30. Jan 1979 to 28. Feb 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Similar to guideline OECD 401 with acceptable restrictions, limited documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EPA guideline (not further specified)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Cyclohexanone oxime
- EC Number:
- 202-874-0
- EC Name:
- Cyclohexanone oxime
- Cas Number:
- 100-64-1
- Molecular formula:
- C6H11NO
- IUPAC Name:
- cyclohexanone oxime
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): cyclohexanone oxime
- Substance type: white crystalline powder
- Storage condition of test material: at room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: CHarles River Breeding Laboratory, Wilmington, USA
- Weight at study initiation: 145-236 g (males) and 138-163 g (females)
- Fasting period before study: overnight
- Housing: groups of two
- Diet (ad libitum): Purina laboratory chow
- Water (ad libitum): source not stated
- Acclimation period: 7 days
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 5000 mg/kg
- Doses:
- males: 562, 794, 1000, 1410, 1590, 2000 and 5000 mg/kg
females: 398, 631, 1000, 2000 and 5000 mg/kg - No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:clinical observations immediately after dosing, then after 1 and 4 h, and twice daily thereafter
- Necropsy of survivors performed: yes - Statistics:
- Probit analysis according to Finney
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 765.01 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1 632 - 1 908.62
- Remarks on result:
- other: Acc. to study report: data obtained excluding the results of the 1000 mg/kg group; including this group the LD50 was 1758.94 (95% CI: 1374.74-2250.52) mg/kg
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 882.82 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 725.88 - 1 073.69
- Mortality:
- Mortality in males:
562 mg/kg: 0
794 mg/kg: 0
1000 mg/kg: 3
1410 mg/kg: 0
1590 mg/kg: 3
2000 mg/kg: 8
5000 mg/kg: 10
Mortality in females:
398 mg/kg: 0
631 mg/kg: 2
1000 mg/kg: 6
2000 mg/kg: 10
5000 mg/kg: 10 - Clinical signs:
- Surviving animals: transient slight to marked depression, rough hair coat, salivation, urine stains, ataxia in all dose groups for 1 - 4 h after administration (up to 2 days at higher doses)
labored respiration, prostration before death - Body weight:
- not recorded
- Gross pathology:
- Discoloration of the spleen was noted in ten male rats dosed at 794 mg/kg of body weight, and in seven males dosed a t the 1590 mg/kg level. Discoloration of the stomach and/or intestines was observed in two males dosed a t the1000 mg/kg level, two males dosed at the 1590 mg/kg level, and four females dosed at 2000 mg/kg of body weight. Dark fluid was observed in the stomach and/or intestines of one male dosed a t 1000 mg/kg of body weight, three males dosed at the 1590 mg/kg level, one female dosed at the 631 mg/kg level, and three females dosed at the 1000 mg/kg level. Compound was noted in the stomach and/or intestines of two males dosed at the 1590 mg/kg level, in seven males and nine females dosed at the 2000 mg/kg level, and in all ten males and females dosed a t the 5000 mg/kg level.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of this study the test substance the LD50 in rats was 883 mg/kg bw for females and 1765 mg/kg bw for males. Therefore the substance has to be classified as harmful if swallowed according to Regulation (EC) No 1272/2008
- Executive summary:
The test substance was evaluated for acute oral toxicity in male and female Fischer 344 rats in a study performed according to EPA guidelines (similar to guideline OECD 401). Groups of 10 animals per sex were exposed to 562, 794, 1000, 1410, 1590, 2000 or 5000 mg/kg (males) or 398, 631, 1000, 2000 or 5000 mg/kg (females). After exposure the animals were observed for 14 days. Surviving animals showed transient slight to marked depression, rough hair coat, salivation, urine stains, and ataxia in all dose groups for 1 - 4 h after administration (up to 2 days at higher doses). Labored respiration and prostration was evident before death. Based upon the findings of this study, the acute oral LD50 was calculated to be 1765.01 and 882.82 mg/kg bw, with 95% confidence limits for males from 1632.20 to 1908.62 mg/kg bw and for females from 725.88 to 1073.69 mg/kg bw.
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