Registration Dossier
Registration Dossier
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EC number: 691-232-7 | CAS number: 474266-68-7
Endpoint summary
Administrative data
Description of key information
No data available - DIBN is instable under normal conditions and testing is not feasible due to technical reasons according REACH Regulation (EC) no 1907_2006 Annex XI
Key value for chemical safety assessment
Additional information
In an acute dermal toxicity study diisobutylen nitrosate (approx. 20% pure) was applied to the clipped, intact skin of 1 male New Zealand White rabbit each at a dose of 1000, 2300 or 3400 mg/kg bw. Additionally 2 rabbits were dosed at 5000 mg/kg bw. The test sites were occluded for 24 hours.
The 2 rabbits treated with 5000 mg/kg bw died within 6 hours following application of the test material; no other deaths occured. Slight to severe erythema and mild edema were observed in the treated rabbits. Other dermal effects observed in the rabbits included necrosis, fissuring and epidermal scaling of the skin. In addition, labored breathing, vocalization, stained fur, convulsions and a change in eye color from pink to black were observed in the treated rabbits.
Justification for classification or non-classification
No studies available and feasible
DIBN is handled under strict controlled conditions - as a protective measure and from the data of the acute dermal toxicity study it is suggested to label DIBN (Diisobutylnitrosat) with R 36/37/38 (irritating to eyes, respiratory system and skin).
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