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EC number: 687-349-8 | CAS number: 173194-95-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Conducted under OECD and EU methods, and under GLP conditions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- (6-hydroxynaphthalen-2-yl)boronic acid
- EC Number:
- 687-349-8
- Cas Number:
- 173194-95-1
- Molecular formula:
- C10H9BO3
- IUPAC Name:
- (6-hydroxynaphthalen-2-yl)boronic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Substance type: off white powder
- Physical state: solid
- Storage condition of test material: room temperatire until 14 October 2013 and then approximately 4° C in the dark
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: supplied by Harlan Laboratories UK Ltd.
- Age at study initiation: 12-20 weeks old
- Weight at study initiation: 2.29 to 3.06kg
- Housing: Suspended cages
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: minimum 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17-23° C
- Humidity (%): 30-70%
- Air changes (per hr): 15 changes per hour
- Photoperiod: 12 hrs dark /12 hrs light
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): At each test site 0.5g of test item, moistened with 0.5ml of distilled water - Duration of treatment / exposure:
- First rabbit was treated with test material on 3 sites on its back and covered with patches. Duration was 3 minutes, 1 hour and 4 hours after application for the 3 test sites.
Second and third Rabbits were treated with test material in one site on their backs , covered with patches and was left there in contact with the skin for 4 hour period. - Observation period:
- Immediately following removal of the patches and approximately 1, 24, 48 and 72 hours later, the test sites were examined for evidence of primary
irritation - Number of animals:
- 3 rabbits
- Details on study design:
- TEST SITE
- Area of exposure: Back of rabbit
- Type of wrap if used: Cotton gauze patch and rabbit was wrapped in an elasticated corset for duration of exposure period.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Any residual test item was removed by gentle swabbing with cotton wool soaked in distilled water
- Time after start of exposure: First Rabbit test substance was removed from 3 different sites after 3 minutes, 1 hour and 4 hours respectively.
Second and Third Rabbit, test substance (1site) was removed after a 4 hour exposure period.
SCORING SYSTEM:
Erythema and Eschar Formation 0
No erythema 1
Very slight erythema (barely perceptible) Well-defined erythema 2
Moderate to severe erythema 3
Severe erythema (beef redness) to eschar formation preventing grading of erythema 4
Edema Formation
No edema 0
Very slight edema (barely perceptible) 1
Slight edema (edges of area well-defined by definite raising) 2
Moderate edema (raised approximately 1 millimeter) 3
Severe edema (raised more than 1 millimeter and extending beyond the area of exposure) 4
The scores for erythema and edema at the 24 and 72-Hour readings were totaled for the three test rabbits and this total was divided by 6 to give the primary irritation index of the test item. The test item was classified according to the following scheme devised by Draize, J.H. (1959):
Primary Irritation Index Classification of Irritancy
0 Non-irritant
> 0 to 2 Mild irritant
> 2 to 5 Moderate irritant
> 5 to 8 Severe irritant
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 72 hoours
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 72 hours
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 72 hours
- Score:
- ca. 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Remarks on result:
- other: A value of 4 was noted in report but only due to a technician error obervation not performed at 24 hr and exact numerical value impossible to report. Left at zero to be consistent with other animals.
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 72 hours
- Score:
- ca. 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Remarks on result:
- other: A value of 4 was noted in report but only due to a technician error obervation not performed at 24 hr.and exact numerical value impossible to report. Left at zero to be consistent with other animals.
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 72 hours
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: 72 hours
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- other: 72 hours
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- other: 72 hours
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Irritant / corrosive response data:
- SKIN REACTIONS
3-Minute Exposure Period:
The individual scores for erythema/eschar and edema are given in Table 1 (attached below) . No evidence of skin irritation was noted during the
study.
1-Hour Exposure Period:
The individual scores for erythema/eschar and edema are given in Table 1 (attached below). No evidence of skin irritation was noted during the
study.
4-Hour Exposure Period:
The individual scores for erythema/eschar and edema are given in Table 2 (attached below). No evidence of skin irritation was noted during the
study.
Body Weight:
Individual body weights and body weight change are given in Table 3 (attached below) . All animals showed expected gain in body weight during the study. - Other effects:
- For animal #2: A value of 4 was noted in report but only due to a technician error obervation not performed and exact numerical value impossible to report. Reprt here as zero to be consistent with other animals.
Any other information on results incl. tables
Results attached below as follows:
Table 1 Individual Skin Reactions Following 3 -Minute and 1 Hour Exposures
Table 2 Individual Skin Reachtions Following 4 -Hour Exposure
Table 2 : Individual Body Weights and Body Weight Change
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test site, the test substance, produced a primary irritation index of 0.0 - 1.3* and was classified as non-irritant to mild irritant to rabbit skin according to the Draize classification scheme. No corrosive effects were noted.
* A value of 1.3 was noted in report but only due to a technician error obervation not performed on animal #2 at 24 hrs and exact numerical value impossible to report. In results section reported as zero to be consistent with other animals.
Therefore, Boronic Acid would not be classified as an irritant according to GHS or EC CLP 1272/2008.
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