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EC number: 633-172-6 | CAS number: 66415-55-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012-11-15 until 2012-12-19
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- other: Commission Regulation (EC) No 440/2008
- Qualifier:
- according to guideline
- Guideline:
- other: Japan MAFF 8147
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 3-(ethenyloxy)propan-1-amine
- EC Number:
- 633-172-6
- Cas Number:
- 66415-55-2
- Molecular formula:
- C5 H11 N O
- IUPAC Name:
- 3-(ethenyloxy)propan-1-amine
- Details on test material:
- - Name of test material (as cited in study report): Aminopropyl Vinyl Ether
- Test substance No: 12/0567-1
- Homogeneity: The test substance was homogenous by visual inspection.
- Analytical purity: > 99.6 corrected area%
- Batch No.: C520/070/2012/2
- Physical state/colour: Liqiud/colourless, clear
- Storage conditions: room temperature; avoid temperatures >25°C
- Storage stabilityl: The stability under storage conditions over the study period was guarenteed by the sponsor, and the sponsor
holds this responsibility.
- Other: Density[g/mL] 0.892
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Wiga GmbH, Sandhofer Weg 7, 97633 Sulzfeld, Germany.
- Age at study initiation: young adult animals (female animals approx. 10 weeks)
- Weight at study initiation: 181 - 190 g
- Housing: The animals were single housed in fully air-conditioned rooms.
- Diet (e.g. ad libitum): VRF1(P); SDS Special Diet Services, 67122 Altrip, Germany
- Water (e.g. ad libitum): tap water ad libtum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 3 °C
- Humidity (%): 30-70
- Air changes (per hr): approx. 10
- Photoperiod (hrs dark / hrs light): 12 h / 12 h
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 300 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 300 mg/kg bw: 6 females
2000 mg/kg bw: 3 females - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Individual body weights shortly before administration, weekly thereafter and on the last day of observation. Recording of clinical signs several times on the day of administration, and at least once daily thereafter each workday.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 - < 2 000 mg/kg bw
- Mortality:
- All animals of the 300 mg/kg bw dose group survived.
All animals of the 2000 mg/kg bw dose group died within hour 0 after administration. - Clinical signs:
- other: Clinical observation in the 2000 mg/kg bw test group revealed poor general state, pronounced dyspnoea, piloerection and salivation in all three animals. Additionally, one animal showed clonic convulsions and respiration noises. In the first 300 mg/kg test
- Gross pathology:
- The following macroscopic pathologic findings were observed in all animals that died in the 2000 mg/kg bw test group: Severe swelling of the
stomach mucosa, dark red discoloration of the stomach content, extensive bleeding in the glandular stomach and forestomach, dark red
discoloration of the small intestine and its content, spotted discoloration of the liver and congestion in the kidneys.
There were no macroscopic pathological findings in the animals sacrificed at the end of observation period (300 mg/kg bw: 6 females).
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- Under the conditions of this study the median lethal dose of Aminopropyl Vinyl Ether after oral administration was found to be greater than 300 mg/kgbw and less than 2000 mg/kg bw in rats.
Based on the results of this study, the test substance has to be classified Acute Tox Cat 4 (Directive 1272/2008 of CLP) and R22 (67/548/EWG).
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