Registration Dossier
Registration Dossier
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EC number: 401-300-8 | CAS number: 86168-95-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Body responsible for the test
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- (25.02.1985)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Body responsible for the test
- IUPAC Name:
- Body responsible for the test
Constituent 1
Test animals
- Species:
- other: rat, Tif:RAIf (SPF)
- Strain:
- other: F3-hybrid of RII 1/Tif x RII 2/Tif
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- other: Distilled water containing 0.5% CMC and 0.1% polysorbate 80
- Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 male and 5 female animals per dose
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
Any other information on results incl. tables
The animals recovered within 13 days.
Signs of toxicity related to dose levels used, time of onset and duration
Local: No treatment related signs of toxicity were observed.
Systemic: Dyspnea, ruffled fur, and abnormal body position were seen, being common symptomes in acute tests. Additonally, diarrhea was observed on day 1 after application.
Effects in organs: No deviations from normal morphology.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 > 2000 mg/kg bw
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