5-(Acetyl-(3-(acetyl-(3,5-bis(2,3-dihydroxypropylcarbamoyl)-2,4,6-triiodophenyl)amino)-2- hydroxypropyl)amino)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide; 5,5'-((2-Hydroxytrimethylene)bis(acetylimino))bis(N,N'-bis(2,3-dihydroxypropyl)-2,4,6- triiodoisophthalamide);

Biodegradation in water: screening tests

Administrative data

Endpoint:

biodegradation in water: ready biodegradability

Type of information:

experimental study

Adequacy of study:

key study

Study period:

01.06-29.06. 1992

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The study and data are well documented and scientifically acceptable.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1992

Report date:

1992

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

ISO DIS 9408 (Ultimate Aerobic Biodegradability - Method by Determining the Oxygen Demand in a Closed Respirometer)

GLP compliance:

not specified

Test material

Reference

Name:

Unnamed

Type:

Constituent

Study design

Oxygen conditions:

aerobic

Inoculum or test system:

activated sludge, adapted

Duration of test (contact time):

28 d

Initial test substance concentration

Initial conc.:

100 mg/L

Results and discussion

% Degradation

Parameter:

% degradation (DOC removal)

Value:

2

Sampling time:

28 d

BOD5 / COD results

BOD5 / COD

Parameter:

BOD5

Value:

4

Any other information on results incl. tables

Mean value of duplicates for DOC, mg/L

Product name	Test conc.	BOD28	DOC0	DOC28	DOC-rem.
Iodixanol	100 mg/l	4	25.0	24.4	2 %

Applicant's summary and conclusion

Interpretation of results:

not inherently biodegradable

Conclusions:

No significant DOC removal was obtained in the course of the test period. A low, but significant BOD was recorded.The product will be classified as not readily biodegradable according to the OECD criteria which require a DOC removal of 70% in 28 days for classification as "readily degradable".