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Diss Factsheets
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EC number: 229-554-3 | CAS number: 6607-34-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study (OECD), GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2400 (Acute Eye Irritation)
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- Department of Toxicology, BASF AG
Test material
- Reference substance name:
- 2,3,7,8-tetrahydro-2,5,8-benzotrioxacycloundecine-1,9-dione
- EC Number:
- 229-554-3
- EC Name:
- 2,3,7,8-tetrahydro-2,5,8-benzotrioxacycloundecine-1,9-dione
- Cas Number:
- 6607-34-7
- Molecular formula:
- C10H16O5
- IUPAC Name:
- 1,4,7-Trioxacyclotridecane-8,13-dione
- Details on test material:
- - Name as cited in report: Adipic acid, cyclic ester with diethyleneglycol
- Analytical purity: ca. 90%
- Physical state: Solid/white
- Storage: refrigerated
- Lot/batch No.: B 74
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: New Zealand White Chbb: NZW (SPF)
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Boehringer Ingelheim Pharma KG
- Sex: Male
- Age at study initiation: young adults
- Weight at study initiation: 3.61 kg - 3.88 kg
- Housing: singly
- Diet: ad libitum, Kliba Labordiaet (the feed was assayed for chemical and microbiological contaminants)
- Water: ad libitum, tap water (drinking water is regularly assayed for chemical contaminants)
- Acclimation period: 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 -24
- Humidity (%): 30 - 70
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: Left eye (no treatment).
- Amount / concentration applied:
- 0.1 ml bulk volume (approx. 52 mg of the pulverised substance).
- Duration of treatment / exposure:
- 24h
- Observation period (in vivo):
- 1 h, 24 h 48 h, 72 h and 7 d after application
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- The test animals were weighed shortly before application of the test substance. The test substance was test substance was applied in a single dose to the conjunctival sac of the right eyelid. 24 h post application of the test substance, and shortly before the 24 h reading, the eyes of the test animals were washed with tap water. A check for mortality or moribund animals was made twice each workday and once on Saturdays, Sundays and on public holidays. Scoring of the changes to the eyes was performed according to guideline directives (adopted February 24, 1987).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- other: 24h, 48h, 72h
- Score:
- 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- other: 24h, 48, 72h
- Score:
- 0.9
- Max. score:
- 1
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 24h, 48h, 72h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- other: 24h, 48h, 72h
- Score:
- ca. 0.67
- Max. score:
- 1
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- other: 24h, 48h, 72h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- other: 24h, 48h, 72h
- Score:
- 1.8
- Max. score:
- 2
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 24h, 48h, 72h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- other: 24h, 48h, 72h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- other: 24h, 48h, 72h
- Score:
- 1.33
- Max. score:
- 2
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- other: 24h, 48h, 72h
- Score:
- 0
- Remarks on result:
- other: Slight swelling (2 animals) and obvious swelling with partial eversion of the eyelids (1 animal) was observed 1 h post application of the test substance. However, the swelling was fully reversed in all animals within 24 h i.e. before the 24 h reading.
- Other effects:
- Slight discharge was observed in 1 animal 1 h post application of the test substance. The effect was fully reversible before the 24 h reading.
Any other information on results incl. tables
Tabulation of irritant response data for each individual animal at each observation time.
Animal |
Cornea score |
Iris |
Redness |
Chemosis |
Discharge |
|
1h |
01 02 03 |
0 0 0 |
0 0 0 |
2 1 2 |
1 1 2 |
0 0 1 |
24h |
01 02 03 |
0 0 0 |
1 0 1 |
2 2 2 |
0 0 0 |
0 0 0 |
48h |
01 02 03 |
0 0 0 |
1 1 1 |
2 2 1 |
0 0 0 |
0 0 0 |
72h |
01 02 03 |
0 0 0 |
1 1 1 |
2 2 1 |
0 0 0 |
0 0 0 |
7d |
01 02 03 |
0 0 0 |
0 0 0 |
0 0 0 |
0 0 0 |
0 0 0 |
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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