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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
in vivo mammalian germ cell study: cytogenicity / chromosome aberration
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
experimental study
Adequacy of study:
key study
Study period:
02.03.1981-13.04.1981
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: This study was conducted scientifically and in accordance with Good Laboratory Practices.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Pharmakon Ref.:281:22-26, 49-58. Reference: Schmid, W., The micronucleus Test, Mutation Research, 31, (1975) 9-15
GLP compliance:
yes
Type of assay:
chromosome aberration assay

Test material

Constituent 1
Chemical structure
Reference substance name:
Iohexol
EC Number:
266-164-2
EC Name:
Iohexol
Cas Number:
66108-95-0
Molecular formula:
C19H26I3N3O9
IUPAC Name:
5-[acetyl(2,3-dihydroxypropyl)amino]-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide

Test animals

Species:
mouse
Strain:
CD-1
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Doses / concentrations
Remarks:
Doses / Concentrations:5000 mg I/kgBasis:no data

Results and discussion

Test results
Sex:
male/female
Genotoxicity:
negative
Vehicle controls validity:
valid
Negative controls validity:
valid
Positive controls validity:
valid

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): negativeThere was no evidence of an increase in the number of micronuclei in any of the treated groups.
Executive summary:

In the micronucleus test conducted in CD-1 mice, iohexol was administered to 4 groups of mice at dosage level of 5 g I/kg either as a single dose, or as two doses separated by 24 hours. There was no evidence of an increase in the number of micronuclei in any of the treated groups.