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Diss Factsheets
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EC number: 700-529-3 | CAS number: 4224-62-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Only brief testing condition was described in this reference.
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- H.F.Symth,Jr., C.P.Carpenter, C.S.Weil, U.C.Pozzani, J.A. Striegel
- Year:
- 1 962
- Bibliographic source:
- American Industry Hygiene Association Journal, vol. 23, 95 - 107 pages (19629
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Single oral dose toxicity is estimated by the gastric intubation of groups of five non-fasted male rats.
The dosages are arranged in a logarithmic series differing by differing by a factor of two.
Based on the mortalities during a 14-day observation period, the most probable LD50 value and its fiducial range are estimated by the method of Thompson using the table of Weil. - GLP compliance:
- not specified
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- 6-Chlorohexanoic acid
- EC Number:
- 700-529-3
- Cas Number:
- 4224-62-8
- Molecular formula:
- C6H11ClO2
- IUPAC Name:
- 6-Chlorohexanoic acid
- Details on test material:
- Information such as purity, compositions and so on, is not availabe in this reference.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Carworth-Wister rat
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Test animals
Source: Lockland
age: four to five weeks
Weight: 90 - 120 grams
Habituation: rats were reared in their colony and maintained from time of weaning.
Fasting: none
Enviromental conditions:
No data
Administration / exposure
- Route of administration:
- other: Gastirc intubation
- Vehicle:
- not specified
- Details on oral exposure:
- Single oral dose toxicity is estimated by the gastric intubation of groups of five non-fasted male rats.
- Doses:
- No data
- No. of animals per sex per dose:
- male five per dose
- Control animals:
- not specified
- Details on study design:
- Single oral dose toxicity is estimated by the gastric intubation of rats.
Based upon mortalities during a 14-day observation period, the most probable LD50 value and its fiducial range is estimated by the method of Thompson using the Table of Weil. - Statistics:
- Thompson's method; Use of moving averages and interpolation to estimate median effective Dose. (ref. W.R. Thompson, Bacteriol. Rev., 11, 115 (1947)
Table of Weil; Table for convenient calculation of median-effective dose (LD50 or ED50), ref. Biometrics, vol. 8, 249 (1952)
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3 080 mg/kg bw
- 95% CL:
- > 2.49 - < 3.81
Applicant's summary and conclusion
- Interpretation of results:
- relatively harmless
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 on acute oral toxicity of this substance is reported as 3080 mg/kg for male rat.
This value corresponds to " not classified" for CLP regulation, so we concluded oral toxicity of this substance is "relatively harmless".
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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