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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
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Diss Factsheets
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EC number: 204-876-7 | CAS number: 128-04-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Key study: Test method according to OECD Guideline 203. The 96h-LC50 for sodium dimethyldithiocarbamate in Poecilia reticulata was determined to be 2.6 mg/l.
Supporting study: No guideline followed. No analytical monitoring was made. The NOEC based on notochord distortion was determined to be 4 ppb (0.004 mg/l). The LC50 was reported to be between 400 and 4000 ppb (equivalent to 0.4 and 4 mg/l, respectively).
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 2.6 mg/L
Additional information
Key study: An acute toxicity test with sodium dimethyldithiocarbamate on Poecilia reticulata was performed in accordance with the OECD Guideline 203. Fishes were exposed to different concentrations of the test substance over a period of 96 hours in a semi-static system. The 96h-LC50 in Poecilia reticulata was determined to be 2.6 mg/l.
Supporting study: In the present study, developing zebrafish were exposed to sodium dimethyldithiocarbamate concentrations of 4, 40, 400 ppb and 4 ppm from 4 to 24 h post-fertilization. Proper axis formation in the exposed embryos was examined using notochord formation as a morphological marker. Besides, in situ hybridization of developmental markers for collagen, muscle and body axis formation was performed. The medial lethal dose (LC50) for the exposed animals was also determined. Sodium dimethyldithiocarbamate elicited notochord distortions with notochord NOEC of 4 ppb (0.004 mg/l). In situ hybridation of developmental markers was perturbed well after cessation of the treatment. The animals developed normally without other overt morphological effects. The LC50 was determined to be between 400 and 4000 ppb (equivalent to 0.4 and 4 mg/l, respectively).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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