Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-487-4 | CAS number: 83-56-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Although rather limited documentation most important information is available
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicological evaluation of Dihydroxynaphthalene , important components of oxidation hair dyes
- Author:
- Wallat S, Bartnik F, Kästner W, Maak N, Potokar M.
- Year:
- 1 985
- Bibliographic source:
- Aerztl.Kosmetol. 15, 356-364
Materials and methods
- Principles of method if other than guideline:
- The test substance was formulated into a so-called basic-cream with a ph about 9.5. the formulations were applied to the back skin of the test rat - shaved 24 hours before applicaion. To prevent oral uptake of the applied radioactivity the treated skin area was covered with a specially designed perforated glass capsule; treatment time: 48 hours
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Naphthalene-1,5-diol
- EC Number:
- 201-487-4
- EC Name:
- Naphthalene-1,5-diol
- Cas Number:
- 83-56-7
- Molecular formula:
- C10H8O2
- IUPAC Name:
- naphthalene-1,5-diol
- Test material form:
- other: cristalline powder
- Details on test material:
- HPLC: no impurities
Constituent 1
- Radiolabelling:
- yes
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- other: a so-called basic cream with a pH of about 9.5
- Duration of exposure:
- 48 hours
- Doses:
- no data
- No. of animals per group:
- no data
- Control animals:
- no
- Details on study design:
- The test substance was formulated into a so-called basic-cream with a ph about 9.5. the formulations were applied to the back skin of the test rat - shaved 24 hours before applicaion. To prevent oral uptake of the applied radioactivity the treated skin area was covered with a specially designed perforated glass capsule; treatment time: 48 hours
Results and discussion
- Signs and symptoms of toxicity:
- not specified
- Dermal irritation:
- not specified
- Absorption in different matrices:
- no data
- Total recovery:
- no data
Percutaneous absorption
- Dose:
- no data
- Parameter:
- percentage
- Absorption:
- >= 7.7 - <= 9.5 %
- Remarks on result:
- other: 48 hours
Applicant's summary and conclusion
- Executive summary:
The test substance was formulated into a so-called basic-cream with a ph about 9.5. the formulations were applied to the back skin of the test rat - shaved 24 hours before application. To prevent oral uptake of the applied radioactivity the treated skin area was covered with a specially designed perforated glass capsule; treatment time: 48 hours. The absorption rate ranges between 7.7 and 9.5 %
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.