Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 234-205-3 | CAS number: 10595-60-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin: corrosive (US EPA, 1991)
Eye: serious eye damage (US EPA, 1991)
Key value for chemical safety assessment
Additional information
Skin irritation
A skin irritation study was conducted on three male and three female albino rabbits. One intact skin test site and one abraded skin test site per rabbit were each treated with 0.5 ml of actual undiluted test material and occluded for 24 hours. Observations for dermal irritation or defects were made 24 and 72 hours after treatment.
The undiluted test material produced an average erythema score of 3.92 (intact skin) and an average edema score of 4.0 (intact skin). Fullthickness necrosis was present on each test site at each observation time. The test substance was therefore corrosive to the skin.
Eye irritation
An eye irritation study was conducted on nine albino rabbits. 0.1 ml of actual undiluted test material was placed at room temperature in the conjunctival sac of the right eye of each animal selected for testing. The treated eyes of three of the animals were each washed with 300 ml of room temperature tap water beginning 30 seconds after treatment.
The undiluted test material produced corneal ulceration in six unwashed eye, conjunctival necrosis in six unwashed eyes. The undilzted test material produced corneal ulceration in three washed eyes, conjunctival necrosis in three washed eyes .
The mean scores (24/48/72 hours) for the unwashed eyes were 2 .67 for corneal opacity, 2 for iris lesions, 2.28 for conjunctival redness and 4 for edema. These effects were not reversible within the observation period of 7 days. The test substance therefore poses the risk of causing serious damage to the eye.
Justification for classification or non-classification
Based on the available skin and eye irritation studies, the substance has to be classified R 34 (Directive 67/548/EEC) and skin corrosion Cat 1C (CLP). This automatically implies a classification with R41 (Directive 67/548/EEC) and eye irritant Cat. 1 (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.