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EC number: 204-451-6 | CAS number: 121-17-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- June- July 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: in accordance with guidelines
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4-chloro-α,α,α-trifluoro-3-nitrotoluene
- EC Number:
- 204-451-6
- EC Name:
- 4-chloro-α,α,α-trifluoro-3-nitrotoluene
- Cas Number:
- 121-17-5
- Molecular formula:
- C7H3ClF3NO2
- IUPAC Name:
- 1-chloro-2-nitro-4-(trifluoromethyl)benzene
- Details on test material:
- - Name of test material (as cited in study report): MN
- Physical state: yellow liquid
- Lot/batch No.: RV7
- Expiration date of the lot/batch: November 1995
- Stability under test conditions: stable
- Storage condition of test material: room temperature (avoid contact with strong bases and oxidizing agents)
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Conelli s.n.c., Arona (NO) - Italy
- Age at receipt: 2-3 months
- Weight at receipt: 2.0-3.0 kg
- Housing: individual metal cages in T06C conditioned rooms. cages were hung on metal racks over a stainless waste system. Measures of cages: 62 X 47.5 X 38 (h) cm.
- Diet (e.g. ad libitum): GLP 2RB15 certificate pelleted diet produced by Charles River Italia's feed licensee Mucedola S.r.l. (Settimo Milanese). the diet was supplemented by the producer with vitamins and trace elements. diet was provided ad libitum to the animals.
- Water (e.g. ad libitum): from the municipal water main system, periodically analyzed, and with acceptance limits within those provided in EEC Directive 80/778. Water was filtered and provided ad libitum by an automatic valve system.
- Acclimation period: about 10 weeks.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ± 2 °C
- Humidity (%): 50 ± 15 %
- Air changes (per hr): about 15/hour
- Photoperiod (hrs dark / hrs light): artificial light with a circadian cycle of 12 hours of light (7 a.m.-7 p.m.)
IN-LIFE DATES: From: June 13, 1994 To: July 22, 1994
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the contralateral eye, not treated.
- Amount / concentration applied:
- 0.1 mL/animal
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 24, 48 and 72 hours after the test article application.
- Number of animals or in vitro replicates:
- 3 males
- Details on study design:
- Bothe eyes of each experimental animal selected for the testing were examined within 24 hours before testing started.
the test article was placed in the conjunctival sac of the right eye of each animal after gently pulling the lower lid away from the eyeball. The lids were then gently held together for about 3- 4 seconds in order to prevent loss of the material. The other eye (left), remaining untreated, served as control. The eyes of the test animals were washed out at 24 hours following the test article instillation.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- other: slight reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- other: slight reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- other: slight reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- other: slight reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- other: slight reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- other: slight reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 1
- Reversibility:
- other: slight reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #1
- Time point:
- 48 h
- Score:
- 1
- Reversibility:
- other: slight reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #1
- Time point:
- 72 h
- Score:
- 0
- Reversibility:
- other: slight reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- other: sligth reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- other: slight reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- other: slight reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- other: slight reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- other: slight reversible
- Remarks on result:
- no indication of irritation
- Other effects:
- No animals died during the observation period.
No clinical signs or behavioral alterations were noted in any treated rabbit.
at the direct examination of the cornea no signs were noted in any rabbit.
At the examnination after instillation of one drop of 1% sodium fluorescein no signs of corneal epihelium defect were evident in any animal.
No signs were observed in iris of any animal.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test substance MN, when administered by ocular route to rabbits under experimental conditions adopted, was considered NOT IRRITANT for the eye.
- Executive summary:
Experimental data obtained from an acute eye irritation study after a single administration of 0.1 mL of the test article MN in the New Zealand White rabbit (3 animals) are given in this report. The test method was in accordance with the EEC Guidelines (B.5) - directive 92/69/EEC and with OECD Guidelines (section 4, subpart 405, paris 1981 and subsequent revisions). for interpreting and scoring the reaction, the guide issued by the U.S. CPSC was used as reference source.
No animals died during the study. No general signs were seen in any animal. At the application site, slight reversible irritative ocular changes were observed in all treated rabbits. no signs were evident 48 -72 hours after the test article application in any animal. The test article is considered NOT IRRITANT.
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