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Diss Factsheets
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EC number: 201-549-0 | CAS number: 84-65-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No data to assess the validity of the results.
Data source
Reference
- Reference Type:
- publication
- Title:
- Materialy k obosnovaniju predelno dopustimoj koncentraciji antrachinona v vozduche rabocej zony
- Author:
- Volodchenko VA et al.
- Year:
- 1 971
- Bibliographic source:
- Gigiena Truda Prof. Zabol. 15(2), 58-59
Materials and methods
- Principles of method if other than guideline:
- Rats were exposed to the test substance via inhalation during 5-6 h per day with a exposure period of 4 months
- GLP compliance:
- no
Test material
- Reference substance name:
- Anthraquinone
- EC Number:
- 201-549-0
- EC Name:
- Anthraquinone
- Cas Number:
- 84-65-1
- Molecular formula:
- C14H8O2
- IUPAC Name:
- 9,10-dihydroanthracene-9,10-dione
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 5-6 h/day during 4 months
- Frequency of treatment:
- Daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.0052 or 0.0122 mg/L
Basis:
no data
- No. of animals per sex per dose:
- No data
- Control animals:
- not specified
- Details on study design:
- - Post-exposure observation period: 1 month
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
No toxic effects were observed at the dose 0.0052 mg/L.
At the dose 0.0122 mg/L the following effects were observed: body weight loss, changes of the bloodpicture (lowered level of haemoglobin, erythrocytopenia, relative reticulopenia); histopathological findings in the lungs: emphysema, atelectasis, cellular proliferation, in particular perivascular hyperemia of the capillaries and exsudation in the alveolar lumen (blood picture normalised during the experimental period, changes of the lung regenerated within the first month after termination of the experiment.
Applicant's summary and conclusion
- Conclusions:
- At the dose 0.0122 mg/L the following effects were observed: body weight loss, changes of the bloodpicture (lowered level of haemoglobin, erythrocytopenia, relative reticulopenia); histopathological findings in the lungs: emphysema, atelectasis, cellular proliferation, in particular perivascular hyperemia of the capillaries and exsudation in the alveolar lumen (blood picture normalised during the experimental period, changes of the lung regenerated within the first month after termination of the experiment).
- Executive summary:
Rats were exposed to the test substance via inhalation during 5-6 h per day with a exposure period of 4 months. No toxic effects were observed at the dose 0.0052 mg/L. At the dose 0.0122 mg/L the following effects were observed: body weight loss, changes of the bloodpicture (lowered level of haemoglobin, erythrocytopenia, relative reticulopenia); histopathological findings in the lungs: emphysema, atelectasis, cellular proliferation, in particular perivascular hyperemia of the capillaries and exsudation in the alveolar lumen (blood picture normalised during the experimental period, changes of the lung regenerated within the first month after termination of the experiment).
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