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EC number: 688-124-7 | CAS number: 152261-43-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin Sensitisation
REACH_not sensitising | KeratinoSens | OECD 442D | #key study##Analogy (152261-44-4)#
REACH_not sensitising | hCLAT | OECD 442E | #key study##Analogy (152261-44-4)#
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vitro
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 2018-04-09 to 2018-05-08
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- Analogy to Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis-, RP with 3-(triethoxysilyl)-1-propanamine, CAS 152261-44-4:
Ethanol, 2,2'-oxybis-, reaction products with 3-(triethoxysilyl)-1-propanamine (CAS 152261-43-3) is a complex reaction mixture (UVCB) of 3-aminopropyltriethoxysilane (CAS 919-30-2) and diethylene glycol (CAS 111-46-69). Diethylene glycol is the main component besides smaller amounts of ethanol (CAS 64-17-5). No free 3-aminopropyltriethoxysilane is detectable, because it is covalently bound to the oligomeric structures of the reaction product.
A comparable reaction mixture namely Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis-, reaction products with 3-(triethoxysilyl)-1-propanamine (CAS 152261-44-4) was submitted to acute toxicity testing. The tested reaction product does contain triethylene glycol instead of diethylene glycol as main component and ethanol. The data on Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis-, reaction products with 3-(triethoxysilyl)-1-propanamine were used for evaluation of the reaction product with diethylene glycol.
Ethanol, 2,2'-oxybis-, reaction products with 3-(triethoxysilyl)-1-propanamine are unstable upon contact with moisture. The product undergoes further condensation reactions that form highly polymerized poly silicic acids while liberating the diethylene glycol, that was initially bound to the oligomeric structures. The underlying chemistry is commonly known as sol-gel reaction. The poly silicic acid moieties are not stable and prone to further condensation generating water insoluble, resinous polymers. The molecular weight of the resulting polymers is predicted to be over 1000. These polymers are stable and not bioavailable.
For the above mentioned reasons the toxicological profile of Ethanol, 2,2'-oxybis-, reaction products with 3-(triethoxysilyl)-1-propanamine will be mainly determined by the solvents, which are very well investigated.
Diethylene glycol and triethylene glycol belong to the group of ethylene glycols represented by the generic molecular structure HO(CH2CH2O)nH, where n = 2-3. Diethylene glycol and triethylene glycol are closely related in structure, both substances possess two terminal hydroxy groups and differ from each other only in the number of one oxyethylene unit. Both substances are total miscibility with water and exhibit a comparable toxicological profile as well as metabolic fate (OECD SIDS Initial Assessment Profile, ethylene glycols, 2004).
Therefore the acute data generated with Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis-, reaction products with 3-(triethoxysilyl)-1-propanamine can be applied to adequately address acute toxicity of Ethanol, 2,2'-oxybis-, reaction products with 3-(triethoxysilyl)-1-propanamine. - Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guidelines for Testing of Chemicals, No. 442E: “In vitro Skin Sensitisation: human Cell Line Activation Test (h-CLAT)” adopted 29 July 2016
- Qualifier:
- according to guideline
- Guideline:
- other: Human Cell Line Activation Test (h-CLAT) for Skin Sensitisation, DB-ALM Protocol n°158, July 1st, 2015
- Key result
- Run / experiment:
- other: 1
- Parameter:
- other: relative fluorescence intensity CD86 [%]
- Value:
- 116
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: Concentration: 11979.17 μg/mL
- Key result
- Run / experiment:
- other: 1
- Parameter:
- other: relative fluorescence intensity CD54 [%]
- Value:
- 122
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: Concentration:14375.00 μg/mL
- Key result
- Run / experiment:
- other: 2
- Parameter:
- other: relative fluorescence intensity CD86 [%]
- Value:
- 119
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: Concentration: 17250.00 μg/mL
- Key result
- Run / experiment:
- other: 2
- Parameter:
- other: relative fluorescence intensity CD54 [%]
- Value:
- 113
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: Concentration: 17250.00 μg/mL
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In this study under the given conditions the test item did not upregulate the expression of the cell surface markers in at least two independent experiment runs. Therefore the test item might be considered as non-sensitiser.
- Endpoint:
- skin sensitisation: in vitro
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 2018-03-27 to 2018-04-10
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- Analogy to Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis-, RP with 3-(triethoxysilyl)-1-propanamine, CAS 152261-44-4:
Ethanol, 2,2'-oxybis-, reaction products with 3-(triethoxysilyl)-1-propanamine (CAS 152261-43-3) is a complex reaction mixture (UVCB) of 3-aminopropyltriethoxysilane (CAS 919-30-2) and diethylene glycol (CAS 111-46-69). Diethylene glycol is the main component besides smaller amounts of ethanol (CAS 64-17-5). No free 3-aminopropyltriethoxysilane is detectable, because it is covalently bound to the oligomeric structures of the reaction product.
A comparable reaction mixture namely Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis-, reaction products with 3-(triethoxysilyl)-1-propanamine (CAS 152261-44-4) was submitted to acute toxicity testing. The tested reaction product does contain triethylene glycol instead of diethylene glycol as main component and ethanol. The data on Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis-, reaction products with 3-(triethoxysilyl)-1-propanamine were used for evaluation of the reaction product with diethylene glycol.
Ethanol, 2,2'-oxybis-, reaction products with 3-(triethoxysilyl)-1-propanamine are unstable upon contact with moisture. The product undergoes further condensation reactions that form highly polymerized poly silicic acids while liberating the diethylene glycol, that was initially bound to the oligomeric structures. The underlying chemistry is commonly known as sol-gel reaction. The poly silicic acid moieties are not stable and prone to further condensation generating water insoluble, resinous polymers. The molecular weight of the resulting polymers is predicted to be over 1000. These polymers are stable and not bioavailable.
For the above mentioned reasons the toxicological profile of Ethanol, 2,2'-oxybis-, reaction products with 3-(triethoxysilyl)-1-propanamine will be mainly determined by the solvents, which are very well investigated.
Diethylene glycol and triethylene glycol belong to the group of ethylene glycols represented by the generic molecular structure HO(CH2CH2O)nH, where n = 2-3. Diethylene glycol and triethylene glycol are closely related in structure, both substances possess two terminal hydroxy groups and differ from each other only in the number of one oxyethylene unit. Both substances are total miscibility with water and exhibit a comparable toxicological profile as well as metabolic fate (OECD SIDS Initial Assessment Profile, ethylene glycols, 2004).
Therefore the acute data generated with Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis-, reaction products with 3-(triethoxysilyl)-1-propanamine can be applied to adequately address acute toxicity of Ethanol, 2,2'-oxybis-, reaction products with 3-(triethoxysilyl)-1-propanamine. - Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 442D (In Vitro Skin Sensitisation: ARE-Nrf2 Luciferase Test Method)
- Qualifier:
- according to guideline
- Guideline:
- other: KeratinoSens™, EURL ECVAM DB-ALM Protocol No. 155, July 1st, 2015
- Key result
- Run / experiment:
- other: 1
- Parameter:
- other: luciferase activity
- Value:
- 1.12
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: Concentration: 0.98 μM
- Key result
- Run / experiment:
- other: 1
- Parameter:
- other: cell viability [%]
- Value:
- 99.4
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Key result
- Run / experiment:
- other: 1
- Parameter:
- other: EC1.5 [μM]
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- not determinable
- Key result
- Run / experiment:
- other: 2
- Parameter:
- other: luciferase activity
- Value:
- 1.1
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: Concentration: 250 μM
- Key result
- Run / experiment:
- other: 2
- Parameter:
- other: cell viability [%]
- Value:
- 100
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Key result
- Run / experiment:
- other: 2
- Parameter:
- other: EC1.5 [μM]
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- not determinable
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In this study under the given conditions the test item did not induce the luciferase activity in the transgenic KeratinoSens™ cell line in at least two independent experiment runs. Therefore, the test item can be considered as non sensitiser.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Ethanol, 2,2’-[1,2-ethanediylbis(oxy)]bis-, reaction products with 3-(triethoxysilyl)-1-propanamine (CAS 152261-44-4) is a reaction mixture of 3-aminopropyltriethoxysilane (CAS 919-30-2) and triethylene glycol (CAS 112-27-6). Triethylene glycol is the main component besides smaller amounts of ethanol (CAS 64-17-5). No free 3-aminopropyltriethoxysilane is detectable. Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis-, reaction products with 3-(triethoxysilyl)-1-propanamine (CAS 152261-44-4) is a close analogue to Ethanol, 2,2'-oxybis-, reaction products with 3-(triethoxysilyl)-1-propanamine (CAS 152261-43-3) and was submitted to an OECD 442D (Keratinosens) and an OECD 442E test (h-CLAT). As a complex reaction product (UVCB), the reaction product does not qualify for testing in an OECD 442C study (DPRA). Ethanol, 2,2’-[1,2-ethanediylbis(oxy)]bis-, reaction products with 3-(triethoxysilyl)-1-propanamine exhibited no sensitizing effects in both studies.
These data were used for evaluation of Ethanol, 2,2’-oxybis-, reaction products with 3-(triethoxysilyl)-1-propanamine, which is based on diethylene glycol (CAS 111-46-6) instead of triethylene glycol. Diethylene glycol is the main component apart from ethanol. The reaction product with diethylene glycol does not contain free 3-aminopropyltriethoxysilane.
Similar to the tested reaction mixture, the reaction product with diethylene glycol is unstable upon contact with moisture. lt undergoes further condensation reactions that form highly polymerized poly silicic acids while liberating the diethylene glycol, that was initially bound to the oligomeric structures. The underlying chemistry is commonly known as sol-gel reaction. The poly silicic acid moieties are not stable and prone to further condensation generating waterinsoluble, resinous polymers. The molecular weight of the resulting polymers is predicted to be over 1000. These polymers are stable and not bioavailable.
Because 3-aminopropyltriethoxysilane is completely consumed into the polymer matrix the toxicological profile of the reaction product with diethylene glycol will be mainly determined by diethylene glycol and to a lesser extent by ethanol.
Neither diethylene glycol nor ethanol exhibit skin sensitizing properties, both solvents are not classified as sensitizers in accordance with Annex VI to Regulation (EC) No 1272/2008. However, it was demonstrated that 3-aminopropyltriethoxysilane is a skin sensitizer in the Buehler test. Hydrolysis products of 3-aminopropyltriethoxysilane did not show sensitizing effects in a guinea pig maximization study (OECD SIDS Initial Assessment Report, 3-aminopropyltriethoxysilane, 2003).
Ethanol, 2,2'-oxybis-, reaction products with 3-(triethoxysilyl)-1-propanamine does not contain free 3-aminopropyltriethoxysilane, which is the only monomer with skin sensitizing properties. 3-Aminopropyltriethoxysilane is incorporated in oligomeric structures which further polymerize. In addition, hydrolyzed 3-aminopropyltriethoxysilane is not sensitizing anymore. The contained solvents diethylene glycol and ethanol are no skin sensitizers. Based on the compositional information and due to polymerization of Ethanol, 2,2'-oxybis-, reaction products with 3-(triethoxysilyl)-1-propanamine no sensitizing effects are expected. This was confirmed by testing of an analogous reaction product in an OECD 442D and OECD 442E study. For this reason, Ethanol, 2,2'-oxybis-, reaction products with 3-(triethoxysilyl)-1-propanamine is not classified as skin sensitizer in a Weight of Evidence approach.
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