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EC number: 241-475-6 | CAS number: 17462-58-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: The different dilutions used in the study produced different LD 50 values. This may be due to hydrolysis or instability of the test substance in the emulsion applied. The study therefore is invalid because the concentration applied is unknown.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Different doses of the test substance is applied i.p. to mice
- GLP compliance:
- no
Test material
- Reference substance name:
- sec-butyl chloroformate
- EC Number:
- 241-475-6
- EC Name:
- sec-butyl chloroformate
- Cas Number:
- 17462-58-7
- Molecular formula:
- C5H9ClO2
- IUPAC Name:
- butan-2-yl carbonochloridate
- Reference substance name:
- sec. Butylchloroformate
- IUPAC Name:
- sec. Butylchloroformate
- Reference substance name:
- XIX/353
- IUPAC Name:
- XIX/353
- Details on test material:
- - Name of test material (as cited in study report): sek. Butylchlorkohlensaeureester ( sec. butyl carbonochloridic acid ester)- Physical state: liquid - Analytical purity: ca. 95 % - Expiration date of the lot/batch: not reported - Stability under test conditions: not reported - Storage condition of test material: not reported
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- mouse
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS - Source: Kisslegg, D - Weight at study initiation: mean male 27-39 g, mean female 24- 32 g no further information given ENVIRONMENTAL CONDITIONS not reported
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: aqueous emulsion with Traganth
- Details on exposure:
- Doses were administered in different concentrations in the vehicle: 12.5 to 50 mg/kg in 0.1%; 25-50 mg/kg in 0.5%, 100 mg/kg in 1%
- Doses:
- 12.5, 16, 25, 50, 100 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days - Frequency of observations and weighing: Weighing was performed at the day of application, on day 7 after application and at the termination of the study. Clinical observations were done several times at day of application and once daily afterwards with the exception of weekends and holidays. - Necropsy of survivors performed: yes - Other examinations performed: clinical signs and mean body weight
- Statistics:
- none
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 50 mg/kg bw
- Remarks on result:
- other: when the test substance was administered in 0.1% concentration
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- < 25 mg/kg bw
- Remarks on result:
- other: when the test substance was administered in 0.5% concentration
- Mortality:
- No mortality observed in all doses up to 50 mg/kg when administered in 0.1% concentration.9/10 animals died in the 25 mg/kg dose group when administered in 0.5% concentration.All animals died in the 50 and 100 mg/kg dose group when administered in 0.5 and 1% concentration, respectively. Late deaths appeared in the 0.5% concentration treatments.
- Clinical signs:
- 100 mg/kg, 50 and 25 mg/kg in 0.5%: directly after injection, high stepping gait with retarded movement of the extremities, gasping, piloerection, sunken flanks, abdominal position avoided. In the observation period abdominal position, gasping, ruffled fur, piloerection, adhering eye lids, slight apathy, sunken flanks; reversible after 14 d in the surviving animal.50 and 25 mg/kg in 0.1%: directly after injection, quiet behaviour, accelerated respiration, closed eye lids, after 4 h ruffled fur, gasping, closed eye lids. In the observation period abdominal position, gasping, ruffled fur, piloerection, adhering lids, slight apathy, adhering eye lids; reversible within 6 d.16 and 12.5 mg/kg in 0.1%: directly after injection accelerated respiration, partly gasping, partly closed eye lids, retarded movements of the extremities, stretching, sunken flanks. In the observation period, accelerated respiration, quiet behaviour, closed eye lids; reversible within 7 d.
- Body weight:
- not reported
- Gross pathology:
- Dead animals: intraabdominal adhesions, 1* vessel injected parts of the duodenumSacrificed animals: adehesions near the liver, 7*cyst fibrosis at the liver undersurface with adhesions there
Applicant's summary and conclusion
- Executive summary:
The different dilutions used in the study produced different LD 50 values. This may be due to hydrolysis or instability of the test substance in the emulsion applied. The study therefore is invalid because the concentration applied is unknown.
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