Registration Dossier
Registration Dossier
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EC number: 401-800-6 | CAS number: 101513-70-6 3,5-DICHLORO-2,4-DIFLUOROBENZOYLFLUORIDE
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3,5-dichloro-2,4-difluorobenzoyl fluoride
- EC Number:
- 401-800-6
- EC Name:
- 3,5-dichloro-2,4-difluorobenzoyl fluoride
- Cas Number:
- 101513-70-6
- Molecular formula:
- C7HCl2F3O
- IUPAC Name:
- 3,5-dichloro-2,4-difluorobenzoyl fluoride
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Number of animals:
- 1
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- other: 1 animal
- Time point:
- other: 1 h
- Score:
- 2.5
- Reversibility:
- no data
- Remarks on result:
- other: Test terminated
- Irritation parameter:
- edema score
- Basis:
- other: 1 animal
- Time point:
- other: 1 h
- Score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: Test terminated
- Irritation parameter:
- erythema score
- Basis:
- other: 1 animal
- Time point:
- other: 1 h
- Score:
- 1
- Reversibility:
- no data
- Remarks on result:
- other: Test terminated
- Other effects:
- The animal was obviously seriously distressed after 10
mins., showing restlessness and excitement. In fact it
broke its back (probably from kicking out). It was humanely
killed within 1 hour. Corrosive effects, grade 4 erythema
and grade 1 oedema were observed. Substance classified as
Corrosive.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
