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EC number: 237-415-3 | CAS number: 13776-88-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- use of dispersant in high concentration
- Justification for type of information:
- The target and source substances are inorganic phosphate compounds. Due to the comparable physico-chemical properties a similar environmental fate is expected for all substances. Both target substance and the source substance aluminium dihydrogen triphosphate are poorly soluble in water. Transport and partitioning are mainly driven by their relatively low water solubility. A certain proportion of the substances will remain undissolved under environmental conditions and undergoes chemical precipitates. Precipitates of aluminium and phosphorus will be further transformed in soil and sediment systems through mineralization, hydrolytic transformation in soils. In pure water metaphosphate hydrolyses slowly to triphosphate. However the hydrolysis speeds up in presence of microorganisms and mineral contents, forming finally orthophosphate and its equilibrium compound, hydrogen- and dihydrogen phosphates, Microorganism catalysed hydrolysis promotes dissolution and transformation of metaphosphate and triphosphates in the environment compartments. As inorganic compounds, target and sources are not be removed by biotic or abiotic degradation and the ion will persist in the environment.
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 305 (Bioconcentration: Flow-through Fish Test)
- Principles of method if other than guideline:
- The study was performed according to “Methods for the Study of New Chemical Substances” (Kanpogyo (Environmental Agency) Notification No 5, Yakuhatsu (Pharmaceutical Affairs Bureau) Notification No 615, Kikyoku (Basic Industries Bureau) 1974 Notification No 392, 13 July 1974, amended 8 October 1998) and “Bioconcentration: Flow-through Fish Test” (OECD Guidelines for Testing of Chemicals: Guideline 305, 14 June 1996).
- GLP compliance:
- yes
- Details on sampling:
- Fish analysis sample:
∙ Measure body weight and length
∙ Cut into small pieces (scissors)
∙ Microcut (in iced water, using a Polytron, for at least 2 min)
Microcut sample:
← Divide into 0.5 g portions (electric analyser balance)
← 4 mol/L Sodium hydroxide*7 4 mL (graduated pipette)
∙ Heat (Teflon pressure-resistant vessel, approx. 150°C, 2 hours)
∙ Cool (freezer, at least 12 hours)
← Water*6 20 mL (measuring cylinder)
∙ Centrifugation (7100 * G, 10 min)
Residue/Supernatent:
∙ Constant volume 50 mL (water*6, graduated flask)
∙ Divide into 2 mL portions
(push-button type liquid microvolume meter)
← Nitric acid 190 µL (push-button type liquid microvolume meter)
∙ Constant volume 25 mL (water*6, graduated flask)
=> AA sample
Water analysis sample:
← Water*6 18 mL (measuring cylinder) (first concentration set only)
← 2 mol/L Sodium hydroxide 400 µL
(push-button type liquid microvolume meter)
∙ Heat (hotplate, approx. 90°C, approx. 10 min)
∙ Cool (leave at room temperature)
← Nitric acid 370 µL (push-button type liquid microvolume meter)
∙ Constant volume 50 mL (water*6, graduated flask)
=> AA sample - Vehicle:
- yes
- Details on preparation of test solutions, spiked fish food or sediment:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method:
- Chemical name of vehicle (dispersant): Sodium polyacrylate
First concentration set:
A stock solution of the test substance was prepared at a concentration of 1894 mg/L by dissolving the test substance and four times its volume of sodium polyacrylate in ion exchanged water using a Clearmix dispersion machine (approximately 1.8 × 104 rpm, approximately 30 minutes).
Second concentration set:
Stock solution was prepared at a test substance concentration of 189.4 mg/L by dissolving the test substance and four times its volume of sodium polyacrylate in ion exchanged water using a Clearmix dispersion machine (approximately 1.8 × 104 rpm, approximately 30 minutes).
Control set:
Stock solution was prepared at 8 g/L by dissolving sodium polyacrylate in ion-exchanged water. - Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- TEST ORGANISM
- Common name:Carp
- Source: in house culture from CERI Kurume Laboratory 19-14 Chuo-machi, Kurume, Fukuoka (830-0023)
- Age at study initiation: young fish
- Length at study initiation: 7.5-9.7 cm
- Description of housing/holding area: Glass water tank of capacity 100 L
- Feeding during test
- Food type: Mixed feed for rearing carp
- Amount: An amount of feed equivalent to approximately 2% of the bodyweight of the fish
- Frequency: twice a day
ACCLIMATION
- Acclimation period: 31 days
- Acclimation conditions (same as test or not): same as test
- Type and amount of food: Mixed feed for rearing carp
Composition of food:
Protein content: ≥43.0%
Fat content:≥3.0%
- Feeding frequency: An amount of feed equivalent to approximately 2% of the bodyweight of the fish was divided into two portions and supplied twice a day.
- Health during acclimation: yes, In the acclimatization tank, the fish were treated in a mixed drug solution comprising Elevage 20 mg/L and sodium chloride 7 g/L, for 24 hours. In the test water tank, they were treated in a mixed drug solution comprising Elevage 20 mg/L and sodium chloride 7 g/L, for 24 hours. - Route of exposure:
- aqueous
- Test type:
- flow-through
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 28 d
- Test temperature:
- 25.3-25.9°C
- pH:
- 8.1-8.3
- Dissolved oxygen:
- 7.8-8.1 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, size, headspace, fill volume: Glass water tank of capacity 100 L
- Renewal rate of test solution (frequency/flow rate): A combination of 2 mL/min stock solution and 800 mL/min test water was supplied to the test tank at 1155 L/day
- No. of organisms per vessel: 29
- No. of vessels per concentration (replicates): 1
- No. of vessels per control: 1
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Water was supplied using the flowing water device assembled at Kurume Laboratory
OTHER TEST CONDITIONS
- Adjustment of pH: No
- Photoperiod: 14 hours of light/10 hours of darkness
- Light intensity: Artificial illumination by white fluorescent light - Nominal and measured concentrations:
- First concentration set: 4.735 mg/L
Second concentration set: 0.4735 mg/L - Type:
- BCF
- Value:
- <= 4.8
- Calculation basis:
- steady state
- Remarks on result:
- other: Conc.in environment / dose:4.735 mg/L
- Type:
- BCF
- Value:
- <= 43
- Calculation basis:
- steady state
- Remarks on result:
- other: Conc.in environment / dose:0.4735 mg/L
Reference
Study results
Test substance concentration in the test water:
The test substance concentration in the test water remained at ≥75% of the stipulated value, as shown in Table 1. Also, the variation in test substance concentration remained within ±20% of the mean measurement value.
Table 1 Test substance concentration in the test water
(unit mg/L)
Concentration set |
After 1 day |
After 6 days |
After 9 days |
After 14 days |
After 22 days |
After 28 days |
Mean (SD) |
||
1 |
4.63 |
3.59 |
3.97 |
4.22 |
4.22 |
4.24 |
4.14 (0.345) |
|
|
2 |
0.542 |
0.457 |
0.426 |
0.492 |
0.449 |
0.453 |
0.470 (0.0412) |
(SD: standard deviation)
Bioconcentration factors
The bioconcentration factors were as shown in Table 2.
The correlation between the Table 2 bioconcentration factors and the exposure times are shown in Figure 1 and Figure 2. During exposure, the bioconcentration factor was <= 4.8 in the first concentration set and <= 43 in the second concentration set.
Table 2 Bioconcentration factors
Concentration set |
After 6 days |
After 9 days |
After 14 days |
After 22 days |
After 28 days |
||
1 |
<=4.8 <=4.8 |
<=4.8 <=4.8 |
<=4.8 <=4.8 |
<=4.8 <=4.8 |
<=4.8 <=4.8 |
||
2 |
<=43 <=43 |
<=43 <=43 |
<=43 <=43 |
<=43 <=43 |
<=43 <=43 |
Steady-state bioconcentration factors
The results show that the bioconcentration factors were far below 100, steady-state was reached after 28 days. The steady-state bioconcentration factors were therefore the bioconcentration factors after 28 days.
Fat content in the fish
The mean fat content in the fish was as follows.
Before starting the experiment 3.54%
After completion of the experiment 3.26%
Observation of the fish
No abnormalities were observed.
Discussion
In the second concentration set water analysis blank test, the mean level of aluminium detected was 0.761 µg. This was due to aluminium present in the test water, and corresponded to 8% of the stipulated concentration in the second concentration set. Aluminium was analysed in the present study, and so these values were not subtracted but included in the test substance exposure when the concentration of the test substance in the test water was calculated.
Description of key information
The substance has a no bioaccumulation potential (BCF ≤43) (read across)
Key value for chemical safety assessment
- BCF (aquatic species):
- 43 dimensionless
Additional information
Aluminium metaphosphate is an inorganic phosphate and will dissociate aluminium and triphosphate ions and further hydrolysed forming various aluminium species and soluble orthophosphate (PO43-) in sewerage systems, sewage treatment plants and in the environment.
The phosphate anion (PO43-) is ubiquitous in natural waters and essential micronutrient for many organisms, it will not bioaccumulate in organisms and food chains.
The bioaccumulation potential of aluminium dihydrogen triphosphate (CAS 13939-25-8), the product of hydrolysis of aluminium metaphosphate, was tested in a GLP guideline study according to OECD 305 under the flow-through conditions. The stock solution of the test item was prepared using sodium polyacrylate as dispersant. Test fish (Cyprinus carpio) were exposed to test concentrations of 4.735 mg/L and 0.4735 mg/L respectively. The test was terminated after 28 days. At a substance concentration of 4.735 mg/L a BCF value≤43 was determined, whereas a BCF≤4.8 was determined at a test substance concentration of 0.4735 mg/L.
The study results demonstrate that the potential of aluminium metaphosphate (CAS 13776-88-0) to bioaccumulate and the risk of secondary poisoning are low.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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