Registration Dossier
Registration Dossier
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EC number: 204-493-5 | CAS number: 121-69-7
Toxicity to reproduction
Administrative data
- Endpoint:
- toxicity to reproduction
- Remarks:
- other: Parent
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- RTECS Number : BX4725000
- Year:
- 2 012
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances);HPV300 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Monocyclic Aromatic Amines (MAA) Category.pdf http://www.epa.gov/HPV/pubs/summaries/aroamin/c13310tc.htm yr:2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from RTECS
- GLP compliance:
- not specified
- Limit test:
- yes
Test material
- Reference substance name:
- N,N-dimethylaniline
- EC Number:
- 204-493-5
- EC Name:
- N,N-dimethylaniline
- Cas Number:
- 121-69-7
- Molecular formula:
- C8H11N
- IUPAC Name:
- N,N-dimethylaniline
- Test material form:
- other: oily
- Details on test material:
- - Name of test material (as cited in study report): N,N-dimethylaniline
- Substance type: Organic
- Physical state: liquid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: unspecified
- Duration of treatment / exposure:
- 7-14 day(s) after conception
Doses / concentrations
- Remarks:
- Doses / Concentrations:
2920 mg/kg
Basis:
no data
Results and discussion
Results: P0 (first parental generation)
General toxicity (P0)
- Clinical signs:
- effects observed, treatment-related
- Description (incidence and severity):
- Reproductive - Maternal Effects - other effects
Effect levels (P0)
- Dose descriptor:
- other: TDLo - Lowest published toxic dose
- Effect level:
- 2 920 other: mg/kg
- Based on:
- test mat.
- Sex:
- female
Results: F1 generation
General toxicity (F1)
- Clinical signs:
- effects observed, treatment-related
- Description (incidence and severity):
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Lowest published toxic dose (TDLo) for N,N-dimethylaniline was found to be 2920 mg/kg when tested on female mouse. Study shows reproductive, maternal Effects.
- Executive summary:
Lowest published toxic dose (TDLo) for N,N-dimethylaniline was found to be 2920 mg/kg when tested on female mouse. Study shows reproductive, maternal Effects.
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