Registration Dossier
Registration Dossier
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EC number: 201-703-7 | CAS number: 86-84-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 1-naphthyl isocyanate
- EC Number:
- 201-703-7
- EC Name:
- 1-naphthyl isocyanate
- Cas Number:
- 86-84-0
- Molecular formula:
- C11H7NO
- IUPAC Name:
- 1-isocyanatonaphthalene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 200 mg/kg bw
2000 mg/kg bw - No. of animals per sex per dose:
- 3
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occured during 14-days experiment.
- Clinical signs:
- other: dose 200 mg/kg bw for males and females: 30 min after application - not to accept feed, shortness of breath, lie on belly, 3 hours after application - not to accept feed, anemic skin, anemic mucous membranes 24 hours after application - no clinical si
- Gross pathology:
- dose 200 mg/kg bw for males and females:
lungs oedema
spleen - granular surface
dose 2000 mg/kg bw for males and females:
lungs oedema
othe rorgans without changes
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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