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Diss Factsheets
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EC number: 204-594-4 | CAS number: 123-04-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
The key study was performed according to OECD guideline 429 in compliance with GLP (BASF SE, 2012). In this study the test item 2-Ethylhexylchloride was assessed for its skin sensitising potential using the Local Lymph Node Assay (LLNA) in CBA/CaCrl mice. Test item solutions at 25, 50, and 100% (w/w) were prepared in the vehicle acetone:olive oil (4+1 v/v). The animals did not show any signs of systemic toxicity or local skin irritation during the course of the study and no cases of mortality were observed.
Stimulation Indices (S.I.) of 2.12, 4.54, and 6.98 were determined with the test item at concentrations of 25, 50, and 100% (w/w) in acetone:olive oil (4+1 v/v), respectively, and an EC3 value of 34.1% (w/w) was calculated. The DPM values showed a statistically significant and biologically relevant increase in all dose groups in comparison to the vehicle control group and furthermore, a clear dose dependent increase in DPM value was observed. This finding was confirmed by the lymph node weight and lymph node cell count, where a statistically significant (p<0.05) and biologically relevant increase was observed in all dose groups in comparison to the vehicle control group. A dose response was also present. The cutoff-value of 1.55 for the lymph node cell count index reported for BALB/c mice for a positive response was exceeded in all test item treated groups.
Conclusion: The test item 2-Ethylhexylchloride was found to be a skin sensitiser under the test conditions of this study.
Migrated from Short description of key information:
Mouse local lymph node assay (LLNA): sensitising
Respiratory sensitisation
Endpoint conclusion
- Additional information:
- Migrated from Short description of key information:
No data available.
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC):
The available experimental test data concerning skin sensitisation are reliable and suitable for the purpose of classification under Directive 67/548/EEC. According to these data the substance is classified as sensitising to the skin (Xi; R43). No classification is warranted concerning respiratory sensitisation due to lacking data.
Classification, Labeling, and Packaging Regulation (EC) No. 1272/2008:
The available experimental test data concerning skin sensitisation are reliable and suitable for the purpose of classification under Regulation (EC) No. 1272/2008. As a result the substance is classified to be sensitising to the skin (Skin sens. Cat. 1B; H317). No classification is warranted concerning respiratory sensitisation due to lacking data.
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