Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 221-660-8 | CAS number: 3179-76-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The key skin irritation/corrosion study found the test material to be corrosive to the skin of a single rabbit (grade 8/8) after a 4-hour exposure in a study conducted in accordance with OECD 404 but not GLP (Hüls AG, 1989). Necrosis was also observed following a 1-hour but not a 3-minute exposure (extremely limited details are provided on the 1-hour and 3 minute exposures).
The key eye irritation study found the test material to be severely irritant to the eyes of a single rabbit in a reliable study conducted according to OECD 405 and GLP (Safepharm Laboratories Ltd., 1987).
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
There are no reliable studies for skin and eye irritation. Therefore the results of the skin and eye corrosion studies are summarised here and used for classification.
There is one reliable study for each of the skin and eye corrosion endpoints. Supporting studies also show that the test substance is at least an irritant, but these studies were extremely poorly reported and do not meet current guideline standards.
The key study for skin irritation was conducted in accordance with OECD 404 but not GLP (Huls AG, 1989). The test substance was found to be corrosive to the skin of a single rabbit following a 4-hour exposure (see Table 5.4.1). Necrosis was also observed following a 1-hour but not a 3-minute exposure (extremely limited details on the 1-hour and 3 minute exposures available).
The key study for eye irritation was conducted according to OECD 405 and GLP (Safepharm Laboratories Ltd., 1987). Complete corneal opacity was recorded at 20 minutes in a single rabbit, with a Draize score of >=98/110 (see Table 5.4.1). Due to the severity of the reaction no further animals were tested.
Justification for selection of skin irritation / corrosion endpoint:
The selected study is the highest quality study available for skin corrosivity. It was conducted according to an appropriate OECD test guideline but not in compliance with GLP.
Justification for selection of eye irritation endpoint:
The selected study is the highest quality study available for eye corrosivity. It was conducted according to an appropriate OECD test guideline and in compliance with GLP.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
On the basis of the available skin irritation/corrosion and eye irritation studies, 3 -(diethoxymethylsilyl) propylamine is classified 'Skin Corr. 1B' with the hazard statement 'H314: Causes severe skin burns and eye damage' according to the criteria of Regulation (EC) No 1272/2008. It is assumed that substances that are corrosive to the skin are also damaging to the eyes, so there is no separate labelling for the eyes. There are no specific data for respiratory irritation/corrosion.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.