Registration Dossier
Registration Dossier
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EC number: 200-813-2 | CAS number: 74-83-9
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Table 1 Overview ofin vitrogenotoxicity studies with Methyl Bromide
Assay |
Test organism |
Result |
Reference |
Fluctuation test |
K. pneumoniae |
Positive |
Kramers, 1985 |
Ames test |
S. typhimurium |
Positive |
Kramers, 1985 Moriya, 1983 Simmon, 1977 |
Mouse lymphoma test |
L5178Y (TK +/-) |
Positive |
Kramers, 1985 |
DNA repair assay |
Primary rat liver cells |
Negative |
Kramers, 1985 |
Table 2 Overview of in vivogenotoxicity studies with Methyl Bromide
Assay |
Test organism |
Result |
Reference |
Cytogenic test |
Rat bone marrow cells |
Negative |
McGregor, 1981 |
Unscheduled DNA synthesis |
Human embryonic intestinal cells |
Negative |
McGregor, 1981 |
Dominant lethal testing |
Rat |
Negative |
McGregor, 1981 |
Short description of key information:
Methyl Bromide has been shown to display some mutagenic potential when assessed under in vitro conditions such as the Fluctuation, Ames and Mouse lymphoma assay. However, no such mutagenic activity was noted in the DNA repair assay or in any of the in vivo tests conducted.
Endpoint Conclusion:
Justification for classification or non-classification
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