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Diss Factsheets
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EC number: 407-330-8 | CAS number: 61571-06-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
oral
rat (28-day): NOAEL (m/f): 150-1000 mg/kg (BASF AG 1991, OECD 407)
dermal
Actually, there is no information available to cover this endpoint.
inhalation
Actually, there is no information available to cover this endpoint
Key value for chemical safety assessment
Additional information
oral
Tetrahydrothiopyran-3-aldehyd was administered to 30 Wistar rats (15 males and 15 females) by gavage for 4 weeks (21 times). A control group (5 per sex) was dosed with vehicle alone (olive oil). The doses were 15 mg/kg body weight, 150 mg/kg body weight and 1,000 mg/kg body weight. Repeated administration of the test substance caused decreased food consumption (only in the first week), decreased body weight gain in males during the course of the study (significantly decreased only the first week), increased water consumption for the last two weeks, salivation after application (not detectable 10 minutes after that), increased alkaline phosphatase in the female animals, decreased chloride in the female animals and statistically significantly increased absolute and relative liver weights in the female animals in the highest dosing group. Diffuse or focal thickening of the forestomach’s wall in both sexes (macroscopically), hyperkeratosis and/or parakeratosis and epithelial hyperplasia in the forestomach of all males and females as well as slight centrolobular single cell necrosis of the liver in both sexes were noted at necropsy. At the mid dose level only minimal hyperkeratosis and epithelial hyperplasia in the forestomach were noted in both sexes, the low dose level produced no findings at all. The observed effects in the forestomach of the rats in the 150 mg/kg body weight group are considered as treatment-related due to the irritative property of the substance but no signs of systemic toxicity have been observed. Based on the results obtained during this oral toxicity study the “no adverse effect level” of Tetrahydrothiopyran-3-aldehyd is in the range lower than 1.000 mg/kg body weight and greater than 150 mg/kg body weight, the NOEL is defined at 15 mg/kg bw and day.
dermal
Actually, there is no information available to cover this endpoint.
inhalation
Actually, there is no information available to cover this endpoint.
Justification for classification or non-classification
oral
Regarding the results of these studies in rats, the subacute NOAEL of the test substance is found to be at 150 mg/kg body weight and the NOEL at 15 mg/kg body weight due to the overall no effects observed. Based on these results and applying the criteria of the EU and GHS system, the test substance is not classified for repeated dose toxicity. Based on the CLP criteria for classification and labeling the test substance needs not to be labeled.
dermal
Actually, there is no information available to cover this endpoint.
inhalation
Actually, there is no information available to cover this endpoint.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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