Registration Dossier
Registration Dossier
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EC number: 700-184-9 | CAS number: 1000172-11-1
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Study period:
- not applicable
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Model is based on accepted principles of skin permeation and diffusion of chemicals through a semi-permeable membrane. It was validated with an extensive database of experimentally measured permeation coefficients and is considered valid for substances with log Kow values in the range from 0 to 4. In this case it is used with a substance with a logKow clearly outside of this range and therefore it's validity is uncertain, at least from a quantitative perspective.
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: QSAR model
- Title:
- Skinperm version 3.0
- Author:
- ten Berge W
- Bibliographic source:
- http://home.planet.nl/~wtberge/
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- not applicable, QSAR method
- GLP compliance:
- no
- Remarks:
- not applicable, QSAR method
Test material
- Reference substance name:
- not available. UVCB substance
- EC Number:
- 700-184-9
- Cas Number:
- 1000172-11-1
- Molecular formula:
- C28-80.H58-162
- IUPAC Name:
- not available. UVCB substance
- Reference substance name:
- Pentadecane, 7-methylene mixed with 1-tetradecene, dimers and trimers, hydrogenated
- IUPAC Name:
- Pentadecane, 7-methylene mixed with 1-tetradecene, dimers and trimers, hydrogenated
- Details on test material:
- Physicochemical parameters used as per chapter 4. Water solubility 0.0001mg/l, molecular weight 445.
Constituent 1
Constituent 2
Test animals
- Species:
- human
Results and discussion
Any other information on results incl. tables
The model estimates the permeation rate for the substance to be 5.9 pg/cm2/hr. Since this substance is outside the range that has been validated, this quantitative figure must be used with caution. However, it does indicate that dermal uptake is likely to be negligible.
Applicant's summary and conclusion
- Conclusions:
- A QSAR model predicts that the permeation rate of the substance through skin is negligible.
- Executive summary:
A QSAR model indicates that the permeation rate of the substance through skin is likely to be negligible.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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