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EC number: 455-790-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- transformation / dissolution of metals and inorganic metal compounds
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- OECD Series on Testing and Assessment No. 29 (23-Jul-2001): Guidance document on transformation/dissolution of metals and metal compounds in aqueous media
- Principles of method if other than guideline:
- The extend of dissolution of Gasir 1 in (adapted) ISO 6341 medium was determined via a simple experimental procedure of agitating various quantities of the test item in pH buffered aqueous media (pH 6, 7.8, and 8.5). Gasir 1 was introduced into the aqueous medium at single loadings of 100 mg/L each. The mixtures were agitated during a 24-hours period and the concentration of dissolved Se, Ge, As, and Sb were measured.
- GLP compliance:
- no
- Type of method:
- other: Transformation/dissolution of metals
- Type of test:
- screening transformation/dissolution test - sparingly soluble metal compounds
- Mean dissolved conc.:
- 2.56 µg/L
- Element analysed:
- Ge
- Loading of aqueous phase:
- 100 mg/L
- Incubation duration:
- 24 h
- Test conditions:
- pH 6
- Type of test:
- screening transformation/dissolution test - sparingly soluble metal compounds
- Mean dissolved conc.:
- 1.18 µg/L
- Element analysed:
- As
- Loading of aqueous phase:
- 100 mg/L
- Incubation duration:
- 24 h
- Test conditions:
- pH 6
- Type of test:
- screening transformation/dissolution test - sparingly soluble metal compounds
- Mean dissolved conc.:
- 1.24 µg/L
- Element analysed:
- Se
- Loading of aqueous phase:
- 100 mg/L
- Incubation duration:
- 24 h
- Test conditions:
- pH 6
- Type of test:
- screening transformation/dissolution test - sparingly soluble metal compounds
- Mean dissolved conc.:
- 30.23 µg/L
- Element analysed:
- Ge
- Loading of aqueous phase:
- 100 mg/L
- Incubation duration:
- 24 h
- Test conditions:
- pH 7.8
- Type of test:
- screening transformation/dissolution test - sparingly soluble metal compounds
- Mean dissolved conc.:
- 0.41 µg/L
- Element analysed:
- As
- Loading of aqueous phase:
- 100 mg/L
- Incubation duration:
- 24 h
- Test conditions:
- pH 7.8
- Type of test:
- screening transformation/dissolution test - sparingly soluble metal compounds
- Mean dissolved conc.:
- 10.35 µg/L
- Element analysed:
- Se
- Loading of aqueous phase:
- 100 mg/L
- Incubation duration:
- 27 h
- Test conditions:
- pH 7.8
- Type of test:
- screening transformation/dissolution test - sparingly soluble metal compounds
- Mean dissolved conc.:
- 23 µg/L
- Element analysed:
- Ge
- Loading of aqueous phase:
- 100 mg/L
- Incubation duration:
- 24 h
- Test conditions:
- pH 8.5
- Type of test:
- screening transformation/dissolution test - sparingly soluble metal compounds
- Mean dissolved conc.:
- 16 µg/L
- Element analysed:
- As
- Loading of aqueous phase:
- 100 mg/L
- Incubation duration:
- 24 h
- Test conditions:
- pH 8.5
- Type of test:
- screening transformation/dissolution test - sparingly soluble metal compounds
- Mean dissolved conc.:
- 15 µg/L
- Element analysed:
- Se
- Loading of aqueous phase:
- 100 mg/L
- Incubation duration:
- 24 h
- Test conditions:
- pH 8.5
- Details on results:
- The highest solubility of GASIR1 after 24-h agitation at 200 rpm was observed at pH 8.5. Maximum dissolved concentrations for Ge, As and Se were 23, 16 and 15 µg/l, respectively.
There was a remarkable abrasion visible in the test containers after 24 h. - Conclusions:
- Interpretation of results (migrated information): insoluble (< 0.1 mg/L)
The highest solubility of GASIR1 (loading of 100 mg/l) after 24-h agitation at 200 rpm was observed at pH 8.5. Maximum dissolved concentrations for Ge, As and Se were 23, 16 and 15 µg/l, respectively. - Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 04/02/2005-24/2/2005
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes
- Type of method:
- column elution method
- Water solubility:
- < 0.1 mg/L
- Temp.:
- 20 °C
- pH:
- ca. 6.3
- Details on results:
- As all the samples showed no significant intensity for each element compared to the blank solution (glass double-distilled water), and all intensities were less than that of the relevant lowest standard (0.1 mg/l), the results were quoted as less than 1.0 x 10-4 g/l for each element analysed.
- Conclusions:
- Interpretation of results (migrated information): insoluble (< 0.1 mg/L)
The water solubility of each of element of the test material has been determined to be less than 1.0 x 10-4 g/l of solution at 20.0 ± 0.5°C. - Executive summary:
Less than 1.0 x 10-4 g/l of solution for each element at 20.0 ± 0.5°C, using the column elution method, Method A6 of Commission Directive 92/69/EEC.
- Endpoint:
- transformation / dissolution of metals and inorganic metal compounds
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The report is not sufficiently documented: no description of the tested substance, no description of analytical method, etc.
- Qualifier:
- according to guideline
- Guideline:
- OECD Series on Testing and Assessment No. 29 (23-Jul-2001): Guidance document on transformation/dissolution of metals and metal compounds in aqueous media
- Deviations:
- yes
- Remarks:
- loading of 0.25 g/l
- GLP compliance:
- no
- Type of method:
- other: Transformation/dissolution of metals
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- < 0.5 µg/L
- Element analysed:
- Ge
- Loading of aqueous phase:
- 250 mg/L
- Incubation duration:
- 7 d
- Test conditions:
- pH 8.5
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- < 0.5 µg/L
- Element analysed:
- As
- Loading of aqueous phase:
- 250 mg/L
- Incubation duration:
- 7 d
- Test conditions:
- pH 8.5
- Type of test:
- full transformation/dissolution test - metals and sparingly soluble metal compounds
- Mean dissolved conc.:
- < 0.5 µg/L
- Element analysed:
- Se
- Loading of aqueous phase:
- 250 mg/L
- Incubation duration:
- 7 d
- Test conditions:
- pH 8.5
- Details on results:
- After 168-h agitation of GASIR1 in the modified ISO 6341 medium at pH 8.5, dissolved concentrations for all elements (Ge, As and Se) were below 0.5 ug/l for the 250 mg/l loading.
- Conclusions:
- Interpretation of results (migrated information): insoluble (< 0.1 mg/L)
After 168-h agitation of GASIR1 in the modified ISO 6341 medium at pH 8.5, dissolved concentrations for all constituents (Ge, As and Se) were below 0.5 µg/l for the 250 mg/l loading.
Referenceopen allclose all
Description of key information
Assessment of the water solubility according to EU method A6 and the extent of dissolution according to OECD29 illustrate that Gasir 1 is highly insoluble.
Key value for chemical safety assessment
Additional information
The Transformation / Dissolution 24-h screening study according to OECD29 is reliable and can be used as key study for this endpoint. In the 24-h screening the highest solubility of GASIR1 (loading of 100 mg/l) was observed at pH 8.5. Maximum dissolved concentrations for Ge, As and Se were 23, 16 and 15 µg/l, respectively.
Supporting studies:
Cuthbert JE & Mulle DM(2005) is a GLP-compliant study following EU method A6. The water solubility of the test item at 20 °C was determined to be < 0.1 mg/l (loadiing of 10 mg/L).
In a Transformation/Dissolution 168-h test (Rodriguez PH (2007)) at pH 8.5, at a loading rate of 250mg/L, dissolved concentrations for all constituents (Ge, As and Se) were below 0.5 µg/l for the 250 mg/l loading.
Interpretation of results: insoluble (< 0.1 mg/L).
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